Diffuse Cutaneous Leishmaniasis Acquired in Peru

Eileen D. Franke U.S. Naval Medical Research Institute Detachment—Lima, Centro Medico Naval, Institute of Pathology, Universidad Nacional Mayor de San Marcos, APO Miami, FL 34031, Peru

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Carmen M. Lucas U.S. Naval Medical Research Institute Detachment—Lima, Centro Medico Naval, Institute of Pathology, Universidad Nacional Mayor de San Marcos, APO Miami, FL 34031, Peru

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Adolfo A. Tovar U.S. Naval Medical Research Institute Detachment—Lima, Centro Medico Naval, Institute of Pathology, Universidad Nacional Mayor de San Marcos, APO Miami, FL 34031, Peru

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J. Hever Kruger U.S. Naval Medical Research Institute Detachment—Lima, Centro Medico Naval, Institute of Pathology, Universidad Nacional Mayor de San Marcos, APO Miami, FL 34031, Peru

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M. Violeta Seminario De Rivera U.S. Naval Medical Research Institute Detachment—Lima, Centro Medico Naval, Institute of Pathology, Universidad Nacional Mayor de San Marcos, APO Miami, FL 34031, Peru

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F. Stephen Wignall U.S. Naval Medical Research Institute Detachment—Lima, Centro Medico Naval, Institute of Pathology, Universidad Nacional Mayor de San Marcos, APO Miami, FL 34031, Peru

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A case of diffuse cutaneous leishmaniasis (DCL) acquired in Peru is described. The causative agent was Leishmania mexicana amazonensis as determined by isoenzyme analysis and species-specific monoclonal antibody binding characteristics. Histological examination of biopsy material showed a large number of intracellular and extracellular amastigotes and few lymphocytes. Treatment with meglumine antimoniate (Glucantime) administered iv at a dosage of 20 mg antimony/kg body weight/day for 60 days resulted in visible improvement of the lesions, but not in clinical or parasitological cure.

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