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Renal Pathology in Owl Monkeys in Plasmodium falciparum Vaccine Trials
Motohiro Iseki
Motohiro Iseki
Institute of Pathology, Case Western Reserve University, Centers for Disease Control, Cleveland, Ohio, Georgia
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J. Roger Broderson
J. Roger Broderson
Institute of Pathology, Case Western Reserve University, Centers for Disease Control, Cleveland, Ohio, Georgia
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Keith G. Pirl
Keith G. Pirl
Institute of Pathology, Case Western Reserve University, Centers for Disease Control, Cleveland, Ohio, Georgia
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Ikuo Igarashi
Ikuo Igarashi
Institute of Pathology, Case Western Reserve University, Centers for Disease Control, Cleveland, Ohio, Georgia
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William E. Collins
William E. Collins
Institute of Pathology, Case Western Reserve University, Centers for Disease Control, Cleveland, Ohio, Georgia
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Masamichi Aikawa
Masamichi Aikawa
Institute of Pathology, Case Western Reserve University, Centers for Disease Control, Cleveland, Ohio, Georgia
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Renal specimens of 16 owl monkeys (Aotus vociferans) were studied by light microscopy and immunohistochemistry during a vaccine trial with recombinant proteins of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum. Deposition of IgG, C3, and P. falciparum antigens in the mesangium was demonstrated by the peroxidase anti-peroxidase (PAP) method. A relationship between the severity of parasitemia at the time of death and the presence of nephropathy was not apparent.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 532 | 257 | 41 |
| Full Text Views | 12 | 3 | 0 |
| PDF Downloads | 11 | 4 | 0 |