Antimalarial Drug Susceptibility of Plasmodium Falciparum Isolates from Forest Fringe Dwelling Aborigines (Orang Asli) of Peninsular Malaysia

Chris Lambros Malaria Research Group, U.S. Army Medical Research Unit, Institute for Medical Research, 50588 Kuala Lumpur, Malaysia

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Donald R. Davis Malaria Research Group, U.S. Army Medical Research Unit, Institute for Medical Research, 50588 Kuala Lumpur, Malaysia

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George E. Lewis Jr. Malaria Research Group, U.S. Army Medical Research Unit, Institute for Medical Research, 50588 Kuala Lumpur, Malaysia

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DOI:
https://doi.org/10.4269/ajtmh.1989.41.1.TM0410010003
Volume/Issue:
Volume 41: Issue 1
Page(s):
3–8
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The drug susceptibility of 70 isolates of Plasmodium falciparum to standard and experimental antimalarials was evaluated using a radioisotope microdilution method. All isolates were from forest fringe dwelling Orang Asli, the aborigines of Peninsular Malaysia. The geometric mean IC50 values were: chloroquine, 10 ng/ml; amodiaquine, 4.7 ng/ml; mefloquine, 2.8 ng/ml; quinine, 40.5 ng/ml; halofantrine, 1.5 ng/ml; enpiroline, 3 ng/ml; and pyrimethamine, 21 ng/ml. Four isolates exhibited decreased susceptibility to chloroquine (IC50 > 60 ng/ml), and one exhibited decreased susceptibility to quinine (IC50 = 161 ng/ml). Three isolates showed decreased susceptibility to mefloquine (IC50 = 10–11 ng/ml). The lack of drug pressure may account for the high prevalence of P. falciparum isolates susceptible to chloroquine.

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Copyright:
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene 1989
Published Online:
Jul 1989
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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