| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 767 | 522 | 76 |
| Full Text Views | 5 | 2 | 0 |
| PDF Downloads | 3 | 3 | 0 |
Single-Dose Chloroquine Therapy for Plasmodium falciparum in Children in Togo, West Africa
Joel G. Breman
Joel G. Breman
Malaria Branch
Search for other papers by Joel G. Breman in
Current site
Google Scholar
PubMed
Search for other papers by Joel G. Breman in
Current site
Google Scholar
PubMed
Anani Gayibor
Anani Gayibor
National Malaria Service
Search for other papers by Anani Gayibor in
Current site
Google Scholar
PubMed
Search for other papers by Anani Gayibor in
Current site
Google Scholar
PubMed
Jacquelin M. Roberts
Jacquelin M. Roberts
Division of Parasitic Diseases, Center for lnfectious Diseases
Search for other papers by Jacquelin M. Roberts in
Current site
Google Scholar
PubMed
Search for other papers by Jacquelin M. Roberts in
Current site
Google Scholar
PubMed
John D. Sexton
John D. Sexton
Malaria Branch
Search for other papers by John D. Sexton in
Current site
Google Scholar
PubMed
Search for other papers by John D. Sexton in
Current site
Google Scholar
PubMed
Kossi Agbo
Kossi Agbo
Parasitology Department, School of Medicine, University of Benin, Lomé, Togo
Search for other papers by Kossi Agbo in
Current site
Google Scholar
PubMed
Search for other papers by Kossi Agbo in
Current site
Google Scholar
PubMed
Kirk D. Miller
Kirk D. Miller
Malaria Branch
Search for other papers by Kirk D. Miller in
Current site
Google Scholar
PubMed
Search for other papers by Kirk D. Miller in
Current site
Google Scholar
PubMed
Tchasseu Karsa
Tchasseu Karsa
Epidemiology Division and Combatting Childhood Communicable Diseases Program, Ministry of Health, Social Affairs and Women's Status
Search for other papers by Tchasseu Karsa in
Current site
Google Scholar
PubMed
Search for other papers by Tchasseu Karsa in
Current site
Google Scholar
PubMed
Kevin Murphy
Kevin Murphy
Search for other papers by Kevin Murphy in
Current site
Google Scholar
PubMed
Search for other papers by Kevin Murphy in
Current site
Google Scholar
PubMed
Chloroquine, in a single dose of 10 mg of base/kg, was given orally to Togolese children <5 years of age as primary therapy for Plasmodium falciparum malaria. A simplified World Health Organization in vivo method was used, as was a sequential analysis procedure for determining if the drug trial was a success or failure. A total of 178 children in 3 regions were treated; 174 (98%) responded successfully, which required a ≥75% reduction in parasites by day 2 and elimination of parasites by day 7. All 4 failures had low blood levels of chloroquine and desethylchloroquine at day 7. A single dose of chloroquine for treating malaria can be considered for those areas of Africa where the efficacy of such therapy is documented, and where an antimalarial drug sensitivity monitoring system is operating.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 767 | 522 | 76 |
| Full Text Views | 5 | 2 | 0 |
| PDF Downloads | 3 | 3 | 0 |