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Hyperimmunoglobulinemia E in the Waorani, an Isolated Amerindian Population
Jonathan E. Kaplan
Jonathan E. Kaplan
Research Service, U.S. Veterans Administration Medical Center, and University of New Mexico Affiliated Hospitals, Albuquerque, Division of Immunology, Duke University School of Medicine, Summer Institute of Linguistics, New Mexico 87106
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James W. Larrick
James W. Larrick
Research Service, U.S. Veterans Administration Medical Center, and University of New Mexico Affiliated Hospitals, Albuquerque, Division of Immunology, Duke University School of Medicine, Summer Institute of Linguistics, New Mexico 87106
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James A. Yost
James A. Yost
Research Service, U.S. Veterans Administration Medical Center, and University of New Mexico Affiliated Hospitals, Albuquerque, Division of Immunology, Duke University School of Medicine, Summer Institute of Linguistics, New Mexico 87106
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The Waorani Indians of Eastern Ecuador have the highest blood levels of immunoglobulin E that have been recorded in a human population. Using a radial immunodiffusion technique for IgE determination, we found the mean plasma IgE concentration for the entire sample (n = 227) to be 11,975 International Units per milliliter (normal: 5–500 IU/ml). The reason for the elevated IgE concentrations is unclear, although genetic factors and a high prevalence of parasitic infection may be involved. Atopic disease is rare among the Waorani as determined by medical history, physical examination, and immediate hypersensitivity skin tests. Our data are consistent with the association between hyperimmunoglobulinemia E and low prevalence of atopic disease in tropical populations. The significance of the findings with regard to the control of allergic disorders is discussed.
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| Past two years | Past Year | Past 30 Days | |
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