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Evaluating New Antimalarial Drugs against Trophozoite Induced Plasmodium Cynomolgi Malaria in Rhesus Monkeys
David E. Davidson Jr.
David E. Davidson Jr.
Department of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand
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Dennis O. Johnsen
Dennis O. Johnsen
Department of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand
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Prayot Tanticharoenyos
Prayot Tanticharoenyos
Department of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand
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Robert L. Hickman
Robert L. Hickman
Department of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand
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Kenneth E. Kinnamon
Kenneth E. Kinnamon
Department of Veterinary Medicine, SEATO Medical Research Laboratory, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Bandkok, Thailand
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An antimalarial drug testing system is described which utilizes trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys. The schizonticidal activity of standard antimalarial drugs in this system is reported. The system accurately predicted anti-malarial activity in man of 8 of 9 compounds selected for clinical trials.
Author Notes
Department of Veterinary Medicine, SEATO Medical Research Laboratory, Bangkok.
Letterman Army Institute of Research.
U. S. Army Medical Research Institute of Infectious Diseases.
Division of Medicinal Chemistry, Walter Reed Army Institute of Research.
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