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The Development of Anti-Immunoglobulin Antibodies in Rhesus Monkeys Repeatedly Exposed to Schistosoma Japonicum
R. Wistar Jr.
R. Wistar Jr.
Clinical and Experimental Immunology Department, Naval Medical Research Institute, Department of Microbiology, The University of Chicago, Bethesda, Maryland 20014
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K. D. Murrell
K. D. Murrell
Clinical and Experimental Immunology Department, Naval Medical Research Institute, Department of Microbiology, The University of Chicago, Bethesda, Maryland 20014
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R. M. Lewert
R. M. Lewert
Clinical and Experimental Immunology Department, Naval Medical Research Institute, Department of Microbiology, The University of Chicago, Bethesda, Maryland 20014
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M. C. Yogore
M. C. Yogore
Clinical and Experimental Immunology Department, Naval Medical Research Institute, Department of Microbiology, The University of Chicago, Bethesda, Maryland 20014
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C. Cole
C. Cole
Clinical and Experimental Immunology Department, Naval Medical Research Institute, Department of Microbiology, The University of Chicago, Bethesda, Maryland 20014
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W. G. Clutter
W. G. Clutter
Clinical and Experimental Immunology Department, Naval Medical Research Institute, Department of Microbiology, The University of Chicago, Bethesda, Maryland 20014
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The development of anti-immunoglobulin (Ig) antibodies in rhesus monkeys repeatedly exposed to Schistosoma japonicum cercariae was studied. Anti-Ig developed in all 8 monkeys exposed 5 times to cercariae of the Formosan strain, while none of 4 monkeys exposed once to the Philippine strain developed such antibodies in the same period. All monkeys developing anti-Ig had specificities for IgA, 6 of 8 for IgM and IgG, and 7 of 8 for rabbit Ig. The persistence of anti-Ig was greatly extended in the monkeys exposed initially to the Formosan strain and then challenged with the Philippine strain. A single monkey exposed once to the Philippine strain developed anti-IgA and anti-rabbit Ig 85 weeks post-infection. No relationship between host reaction to trapped eggs and the development of anti-Ig was discerned. The results suggest that immunization protocols designed for humans be carefully examined for their potential immunopathological side effects.
Author Notes
Clinical and Experimental Immunology Department, Naval Medical Research Institute.
Department of Microbiology, The University of Chicago.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 432 | 180 | 27 |
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| PDF Downloads | 3 | 2 | 0 |