Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2010. First WHO Report on Neglected Disease. Geneva, Switzerland: WHO.
-
2.
Abadías-Granado I, Diago A, Cerro PA, Palma-Ruiz AM, Gilaberte Y, 2021. Cutaneous and mucocutaneous leishmaniasis. Actas Dermosifiliogr 112: 601–618.
-
3.
World Health Organization, 2023. Lesihmaniasis. Geneva, Switzerland: WHO.
-
4.
Miranda Lessa M, Andrade Lessa H, Castro TWN, Oliveira A, Scherifer A, Machado P, Carvalho EM, 2007. Mucosal leishmaniasis: Epidemiological and clinical aspects. Braz J Otorhinolaryngol 73: 843–847.
-
5.
Goto H, Lindoso JAL, 2010. Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Expert Rev Anti Infect Ther 8: 419–433.
-
6.
Mann S, Frasca K, Scherrer S, Henao-Martínez AF, Newman S, Ramanan P, Suarez JA, 2021. A review of leishmaniasis: Current knowledge and future directions. Curr Trop Med Rep 8: 121–132.
-
7.
Aliaga L, Cobo F, Mediavilla JD, Bravo J, Osuna A, Amador JM, Martin-Sanchez J, Cordero E, Navarro JM, 2003. Localized mucosal leishmaniasis due to Leishmania (Leishmania) infantum: Clinical and microbiologic findings in 31 patients. Medicine (Baltimore) 82: 147–158.
-
8.
Guery R et al.; LeishMan Network and the French Cutaneous Leishmaniasis Study Group, 2021. Clinical diversity and treatment results in tegumentary leishmaniasis: A European clinical report in 459 patients. PLoS Negl Trop Dis 15: e0009863.
-
9.
Bennett JH, 2015. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, PA: Elsevier/Saunders.
-
10.
Strazzulla A, Cocuzza S, Pinzone MR, Postorino MC, Cosentino S, Serra A, Cacopardo B, Nunnari G, 2013. Mucosal leishmaniasis: An underestimated presentation of a neglected disease. Biomed Res Int 2013: 805108.
-
11.
Cantanhêde LM, Mattos CB, Cruz AK, Ikenohuchi YJ, Fernandes FG, Medeiros EHRT, da Silva-Junior CF, Cupolillo E, Ferreira GEM, Ferreira RdGM, 2021. Overcoming the negligence in laboratory diagnosis of mucosal leishmaniasis. Pathogens 10: 1116.
-
12.
Dueñas E, Nakamoto JA, Cabrera-Sosa L, Huaihua P, Cruz M, Arevalo J, Milon P, Adaui V, 2022. Novel CRISPR-based detection of Leishmania species. Front Microbiol 13: 958693.
-
13.
Sampaio RNR, Silva JSFE, de Paula CDR, Porto C, da Motta JdOC, Pereira LIdA, Martins SS, Barroso DH, Freire GSM, Gomes CM, 2019. A randomized, open-label clinical trial comparing the long-term effects of miltefosine and meglumine antimoniate for mucosal leishmaniasis. Rev Soc Bras Med Trop 52: e20180292.
-
14.
Carvalho JP, Silva SN, Freire ML, Alves LL, Souza CSA, Cota G, 2022. The cure rate after different treatments for mucosal leishmaniasis in the Americas: A systematic review. PLoS Negl Trop Dis 16: e0010931.
-
15.
Mili AF, Saghrouni F, BenSaid Z, Saadi-BenAoun Y, Guizani I, BenSaid M, 2012. Retrospective analysis of leishmaniasis in central Tunisia: An update on emerging epidemiological trends. Rodriguez-Morales AJ, ed. Current Topics in Tropical Medicine. London, United Kingdom: InTech, 227–252.
-
16.
Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, Cano J, Jannin J, de Boer M; WHO Leishmaniasis Control Team, 2012. Leishmaniasis worldwide and global estimates of its incidence. PLoS One 7: e35671.
-
17.
Aoun K, Ben Abda I, Bousslimi N, Bettaieb J, Siala E, Ben Abdallah R, Benmously R, Bouratbine A, 2012. Comparative characterization of skin lesions observed in the three endemic varieties of cutaneous leishmaniasis in Tunisia. Ann Dermatol Venereol 139: 452–458.
-
18.
Kharfi M, Fazaa B, Chaker E, Kamoun MR, 2003. Mucosal localization of leishmaniasis in Tunisia: 5 cases. Ann Dermatol Venereol 130: 27–30.
-
19.
El Fékih N, Sliti N, Kharfi M, Trabelsi S, Khaled S, Fazaa B, Kamoun MR, 2008. Mucosal leishmaniasis by contiguity with a skin lesion: Another case report from Tunisia. Med Trop (Mars) 68: 634–636.
-
20.
Benmously-Mlika R, Fenniche S, Kerkeni N, Aoun K, Khedim A, Mokhtar I, 2008. Primary Leishmania infantum MON-80 endonasal leishmaniasis in Tunisia. Ann Dermatol Venereol 135: 389–392.
-
21.
Benmously-Mlika R, Ben Hamida M, Hammami Ghorbel H, Aoun K, Jennet SB, Marrak H, Fenniche S, Mokhtar I, 2011. La leishmaniose muqueuse en Tunisie: Étude de 12 cas. Ann Dermatol Venereol 138: A248–A249.
-
22.
Zaouali A, Abdennadher F, Belhouane J, Gabbouj A, Ghariani N, Denguezli M, Belajouza C, Nouira R, 2013. Formes muqueuses de leishmaniose cutanée en Tunisie. Ann Dermatol Venereol 140: S81.
-
23.
Hammami-Ghorbel H, Ben Abda I, Badri T, Chelbi H, Fenniche S, Mokhtar I, Bouratbine A, Benmously-Mlika R, Aoun K, 2015. Mucosal leishmaniasis of the lip: An emerging clinical form in Tunisia. J Eur Acad Dermatol Venereol 29: 1212–1215.
-
24.
Kidar A et al., 2016. La leishmaniose muqueuse chez l’enfant en Tunisie: Étude de 25 cas. Ann Dermatol Venereol 143: S343.
-
25.
Haouas N et al., 2007. Leishmaniasis in central and southern Tunisia: Current geographical distribution of zymodemes. Parasite 14: 239–246.
-
26.
Amato VS, Tuon FF, Siqueira AM, Nicodemo AC, Neto VA, 2007. Treatment of mucosal leishmaniasis in Latin America: Systematic review. Am J Trop Med Hyg 77: 266–274.
-
27.
Rodrigues MG, Hueb M, 2014. Management of leishmaniasis in clinical practice. J European Acad. Dermatol Venereol 28: 133–139.
-
28.
Aronson N, Herwaldt BL, Libman M, Pearson R, Lopez-Velez R, Weina P, Carvalho EM, Ephros M, Jeronimo S, Magill A, 2016. Diagnosis and treatment of leishmaniasis: Clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Clin Infect Dis 63: e202–e264.
-
29.
Seklaoui N, Izri A, Tablit I, Chergou M, Hamrioui B, Akhoundi M, 2024. Case report: First report of mucocutaneous leishmaniasis in Algeria: Observations from a case report. Am J Trop Med Hyg 111: 377–379.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 8673 | 8673 | 2277 |
| Full Text Views | 27 | 27 | 4 |
| PDF Downloads | 17 | 17 | 9 |
Mucosal Leishmaniasis in Tunisia: Observations from a Rare Case Report
Hamed Chouaieb
Hamed Chouaieb
Laboratory of Parasitology - Mycology, Farhat Hached University Hospital, Sousse, Tunisia;
Parasitology-Mycology Department, Avicenne Hospital, AP-HP, Bobigny, Sorbonne Paris Nord University, Bobigny, France;
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
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Parasitology-Mycology Department, Avicenne Hospital, AP-HP, Bobigny, Sorbonne Paris Nord University, Bobigny, France;
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
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Mohammad Akhoundi
m.akhoundi@yahoo.com
Mohammad Akhoundi
Parasitology-Mycology Department, Avicenne Hospital, AP-HP, Bobigny, Sorbonne Paris Nord University, Bobigny, France;
Unité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica), Marseille, France;
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Unité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica), Marseille, France;
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Malika El Omri
Malika El Omri
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
Department of Ear, Nose, Throat and Head and Neck Surgery, Farhat Hached University Hospital, Sousse, Tunisia;
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Department of Ear, Nose, Throat and Head and Neck Surgery, Farhat Hached University Hospital, Sousse, Tunisia;
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Samar Ismail
Samar Ismail
Laboratory of Parasitology - Mycology, Farhat Hached University Hospital, Sousse, Tunisia;
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
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Faculty of Medicine, University of Sousse, Sousse, Tunisia;
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Imen Khammari
Imen Khammari
Laboratory of Parasitology - Mycology, Farhat Hached University Hospital, Sousse, Tunisia;
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
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Faculty of Medicine, University of Sousse, Sousse, Tunisia;
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Foued Bellazreg
Foued Bellazreg
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
Department of Infectious Diseases, Farhat Hached University Hospital, Sousse, Tunisia
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Department of Infectious Diseases, Farhat Hached University Hospital, Sousse, Tunisia
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Mouna Bellakhdher
Mouna Bellakhdher
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
Department of Ear, Nose, Throat and Head and Neck Surgery, Farhat Hached University Hospital, Sousse, Tunisia;
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Department of Ear, Nose, Throat and Head and Neck Surgery, Farhat Hached University Hospital, Sousse, Tunisia;
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Mohamed Abdelkefi
Mohamed Abdelkefi
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
Department of Ear, Nose, Throat and Head and Neck Surgery, Farhat Hached University Hospital, Sousse, Tunisia;
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Department of Ear, Nose, Throat and Head and Neck Surgery, Farhat Hached University Hospital, Sousse, Tunisia;
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Wissem Hachfi
Wissem Hachfi
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
Department of Infectious Diseases, Farhat Hached University Hospital, Sousse, Tunisia
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Department of Infectious Diseases, Farhat Hached University Hospital, Sousse, Tunisia
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Akila Fathallah
Akila Fathallah
Laboratory of Parasitology - Mycology, Farhat Hached University Hospital, Sousse, Tunisia;
Faculty of Medicine, University of Sousse, Sousse, Tunisia;
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Faculty of Medicine, University of Sousse, Sousse, Tunisia;
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ABSTRACT.
Mucosal leishmaniasis (ML) is a parasitic disease affecting the mucosa of the upper respiratory tract and oral cavity. It is most prevalent in Central and South America, whereas cases in the Old World are relatively rare. Herein, we present the case of an immunocompetent man from Tunisia with a long-delayed diagnosis of ML, characterized by lesions in the nasal mucosa without cutaneous involvement. This report underlines the importance of multidisciplinary care and adherence to follow-up in managing this disease. Clinicians should remain vigilant regarding this parasitosis, its potential complications, and the need for accurate diagnosis and treatment.
- Supplemental Materials (PDF 188.23 KB)
Author Notes
Disclosures: This study was conducted in accordance with the guidelines of the Declaration of Helsinki and was approved by the Institutional Ethics Committee of Avicenne Hospital (protocol code 95/99/AVC/ESA). Informed written consent was obtained from the patient, which included the authorization for the publication of clinical information.
Current contact information: Hamed Chouaieb, Samar Ismail, Imen Khammari, Akila Fathallah, Laboratory of Parasitology - Mycology, Farhat Hached University Hospital, Sousse, Tunisia, E-mails: hamedchouaieb89@gmail.com, samarismail16@yahoo.fr, imenkhammari@yahoo.fr, and fathallahakila@gmail.com. Mohammad Akhoundi, Parasitology-Mycology Department, Avicenne Hospital, AP-HP, Bobigny, Sorbonne Paris Nord University, Bobigny, France, and Unité des Virus Émergents (Aix-Marseille Univ, Università di Corsica), Marseille, France, E-mail: m.akhoundi@yahoo.com. Malika El Omri, Mouna Bellakhdher, and Mohamed Abdelkefi, Department of Ear, Nose, Throat and Head and Neck Surgery, Farhat Hached University Hospital, Sousse, Tunisia, E-mails: omri.malika6@gmail.com, mounabelakhdher@yahoo.com, and abdelkefi_mohamed@yahoo.fr. Foued Bellazreg and Wissem Hachfi, Department of Infectious Diseases, Farhat Hached University Hospital, Sousse, Tunisia, E-mails: fouedbellazreg@yahoo.fr and wissemhachfi@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2010. First WHO Report on Neglected Disease. Geneva, Switzerland: WHO.
-
2.
Abadías-Granado I, Diago A, Cerro PA, Palma-Ruiz AM, Gilaberte Y, 2021. Cutaneous and mucocutaneous leishmaniasis. Actas Dermosifiliogr 112: 601–618.
-
3.
World Health Organization, 2023. Lesihmaniasis. Geneva, Switzerland: WHO.
-
4.
Miranda Lessa M, Andrade Lessa H, Castro TWN, Oliveira A, Scherifer A, Machado P, Carvalho EM, 2007. Mucosal leishmaniasis: Epidemiological and clinical aspects. Braz J Otorhinolaryngol 73: 843–847.
-
5.
Goto H, Lindoso JAL, 2010. Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Expert Rev Anti Infect Ther 8: 419–433.
-
6.
Mann S, Frasca K, Scherrer S, Henao-Martínez AF, Newman S, Ramanan P, Suarez JA, 2021. A review of leishmaniasis: Current knowledge and future directions. Curr Trop Med Rep 8: 121–132.
-
7.
Aliaga L, Cobo F, Mediavilla JD, Bravo J, Osuna A, Amador JM, Martin-Sanchez J, Cordero E, Navarro JM, 2003. Localized mucosal leishmaniasis due to Leishmania (Leishmania) infantum: Clinical and microbiologic findings in 31 patients. Medicine (Baltimore) 82: 147–158.
-
8.
Guery R et al.; LeishMan Network and the French Cutaneous Leishmaniasis Study Group, 2021. Clinical diversity and treatment results in tegumentary leishmaniasis: A European clinical report in 459 patients. PLoS Negl Trop Dis 15: e0009863.
-
9.
Bennett JH, 2015. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, PA: Elsevier/Saunders.
-
10.
Strazzulla A, Cocuzza S, Pinzone MR, Postorino MC, Cosentino S, Serra A, Cacopardo B, Nunnari G, 2013. Mucosal leishmaniasis: An underestimated presentation of a neglected disease. Biomed Res Int 2013: 805108.
-
11.
Cantanhêde LM, Mattos CB, Cruz AK, Ikenohuchi YJ, Fernandes FG, Medeiros EHRT, da Silva-Junior CF, Cupolillo E, Ferreira GEM, Ferreira RdGM, 2021. Overcoming the negligence in laboratory diagnosis of mucosal leishmaniasis. Pathogens 10: 1116.
-
12.
Dueñas E, Nakamoto JA, Cabrera-Sosa L, Huaihua P, Cruz M, Arevalo J, Milon P, Adaui V, 2022. Novel CRISPR-based detection of Leishmania species. Front Microbiol 13: 958693.
-
13.
Sampaio RNR, Silva JSFE, de Paula CDR, Porto C, da Motta JdOC, Pereira LIdA, Martins SS, Barroso DH, Freire GSM, Gomes CM, 2019. A randomized, open-label clinical trial comparing the long-term effects of miltefosine and meglumine antimoniate for mucosal leishmaniasis. Rev Soc Bras Med Trop 52: e20180292.
-
14.
Carvalho JP, Silva SN, Freire ML, Alves LL, Souza CSA, Cota G, 2022. The cure rate after different treatments for mucosal leishmaniasis in the Americas: A systematic review. PLoS Negl Trop Dis 16: e0010931.
-
15.
Mili AF, Saghrouni F, BenSaid Z, Saadi-BenAoun Y, Guizani I, BenSaid M, 2012. Retrospective analysis of leishmaniasis in central Tunisia: An update on emerging epidemiological trends. Rodriguez-Morales AJ, ed. Current Topics in Tropical Medicine. London, United Kingdom: InTech, 227–252.
-
16.
Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, Cano J, Jannin J, de Boer M; WHO Leishmaniasis Control Team, 2012. Leishmaniasis worldwide and global estimates of its incidence. PLoS One 7: e35671.
-
17.
Aoun K, Ben Abda I, Bousslimi N, Bettaieb J, Siala E, Ben Abdallah R, Benmously R, Bouratbine A, 2012. Comparative characterization of skin lesions observed in the three endemic varieties of cutaneous leishmaniasis in Tunisia. Ann Dermatol Venereol 139: 452–458.
-
18.
Kharfi M, Fazaa B, Chaker E, Kamoun MR, 2003. Mucosal localization of leishmaniasis in Tunisia: 5 cases. Ann Dermatol Venereol 130: 27–30.
-
19.
El Fékih N, Sliti N, Kharfi M, Trabelsi S, Khaled S, Fazaa B, Kamoun MR, 2008. Mucosal leishmaniasis by contiguity with a skin lesion: Another case report from Tunisia. Med Trop (Mars) 68: 634–636.
-
20.
Benmously-Mlika R, Fenniche S, Kerkeni N, Aoun K, Khedim A, Mokhtar I, 2008. Primary Leishmania infantum MON-80 endonasal leishmaniasis in Tunisia. Ann Dermatol Venereol 135: 389–392.
-
21.
Benmously-Mlika R, Ben Hamida M, Hammami Ghorbel H, Aoun K, Jennet SB, Marrak H, Fenniche S, Mokhtar I, 2011. La leishmaniose muqueuse en Tunisie: Étude de 12 cas. Ann Dermatol Venereol 138: A248–A249.
-
22.
Zaouali A, Abdennadher F, Belhouane J, Gabbouj A, Ghariani N, Denguezli M, Belajouza C, Nouira R, 2013. Formes muqueuses de leishmaniose cutanée en Tunisie. Ann Dermatol Venereol 140: S81.
-
23.
Hammami-Ghorbel H, Ben Abda I, Badri T, Chelbi H, Fenniche S, Mokhtar I, Bouratbine A, Benmously-Mlika R, Aoun K, 2015. Mucosal leishmaniasis of the lip: An emerging clinical form in Tunisia. J Eur Acad Dermatol Venereol 29: 1212–1215.
-
24.
Kidar A et al., 2016. La leishmaniose muqueuse chez l’enfant en Tunisie: Étude de 25 cas. Ann Dermatol Venereol 143: S343.
-
25.
Haouas N et al., 2007. Leishmaniasis in central and southern Tunisia: Current geographical distribution of zymodemes. Parasite 14: 239–246.
-
26.
Amato VS, Tuon FF, Siqueira AM, Nicodemo AC, Neto VA, 2007. Treatment of mucosal leishmaniasis in Latin America: Systematic review. Am J Trop Med Hyg 77: 266–274.
-
27.
Rodrigues MG, Hueb M, 2014. Management of leishmaniasis in clinical practice. J European Acad. Dermatol Venereol 28: 133–139.
-
28.
Aronson N, Herwaldt BL, Libman M, Pearson R, Lopez-Velez R, Weina P, Carvalho EM, Ephros M, Jeronimo S, Magill A, 2016. Diagnosis and treatment of leishmaniasis: Clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Clin Infect Dis 63: e202–e264.
-
29.
Seklaoui N, Izri A, Tablit I, Chergou M, Hamrioui B, Akhoundi M, 2024. Case report: First report of mucocutaneous leishmaniasis in Algeria: Observations from a case report. Am J Trop Med Hyg 111: 377–379.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 8673 | 8673 | 2277 |
| Full Text Views | 27 | 27 | 4 |
| PDF Downloads | 17 | 17 | 9 |