Author:
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1.
Antimicrobial Resistance Collaborators, 2022. Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Lancet 399: 629–655.
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2.
Jernigan JA et al., 2020. Multidrug-resistant bacterial infections in U.S. hospitalized patients, 2012–2017. N Engl J Med 382: 1309–1319.
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3.
Goodman KE, Lessler J, Cosgrove SE, Harris AD, Lautenbach E, Han JH, Milstone AM, Massey CJ, Tamma PD; Antibacterial Resistance Leadership Group, 2016. A clinical decision tree to predict whether a bacteremic patient is infected with an extended-spectrum β-lactamase-producing organism. Clin Infect Dis 63: 896–903.
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4.
Park YS, Adams-Haduch JM, Shutt KA, Yarabinec DM, Johnson LE, Hingwe A, Lewis JS, Jorgensen JH, Doi Y, 2012. Clinical and microbiologic characteristics of cephalosporin-resistant Escherichia coli at three centers in the United States. Antimicrob Agents Chemother 56: 1870–1876.
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5.
Liu EW, Buss SN, Trumbo JL, Temples TM, 2021. Clinical and demographic features associated with infections with extended-spectrum beta-lactamase-producing Escherichia coli in a health system in Maine, 2017. Antimicrob Steward Healthc Epidemiol 1: e7.
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Christian NA, Roye-Green K, Smikle M, 2010. Molecular epidemiology of multidrug resistant extended spectrum beta-lactamase producing Klebsiella pneumoniae at a Jamaican hospital, 2000–2004. BMC Microbiol 10: 27.
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Nicholson AM, Ledgister S, Williams T, Robinson S, Gayle P, Lindo T, Castle D, Shaw K, Moonah S, 2009. Distribution of nosocomial organisms and their resistance patterns in the intensive care unit of the University Hospital of the West Indies, Kingston, Jamaica. West Indian Med J 58: 142–148. PubMed PMID: WOS:000269356800013.
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8.
Thoms-Rodriguez C-A, Mazzulli T, Christian N, Willey BM, Boyd DA, Mataseje LF, Mulvey MR, Christie CDC, Nicholson AM, 2016. New Delhi metallo-β-lactamase in Jamaica. J Infect Dev Ctries 10: 183–187.
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9.
Kang C-I, Wi YM, Lee MY, Ko KS, Chung DR, Peck KR, Lee NY, Song J-H, 2012. Epidemiology and risk factors of community onset infections caused by extended-spectrum β-lactamase-producing Escherichia coli strains. J Clin Microbiol 50: 312–317.
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10.
Rodríguez‐Baño J et al., 2010. Community-onset bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli: Risk factors and prognosis. Clin Infect Dis 50: 40–48.
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11.
Sogaard M, Heide-Jorgensen U, Vandenbroucke JP, Schonheyder HC, Vandenbroucke-Grauls C, 2017. Risk factors for extended-spectrum β-lactamase-producing Escherichia coli urinary tract infection in the community in Denmark: A case-control study. Clin Microbiol Infect 23: 952–960.
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World Bank Rural Population (% of total population): The World Bank, 2020. Available at: https://data.worldbank.org/indicator/SP.RUR.TOTL.ZS?locations=JM. Accessed May 24, 2024.
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Obeng-Nkrumah N, Twum-Danso K, Krogfelt KA, Newman MJ, 2013. High levels of extended-spectrum beta-lactamases in a major teaching hospital in Ghana: The need for regular monitoring and evaluation of antibiotic resistance. Am J Trop Med Hyg 89: 960–964.
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Clinical and Demographic Features Associated with the Isolation of Ceftriaxone-Resistant Enterobacteriaceae in a Private Hospital in Kingston, Jamaica
Matthew S. Mendoza
Matthew S. Mendoza
Loma Linda University School of Medicine, Loma Linda, California;
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Fredricka A. Coombs
Fredricka A. Coombs
Andrews Memorial Hospital, Kingston, Jamaica
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Hansel M. Fletcher
Hansel M. Fletcher
Loma Linda University School of Medicine, Loma Linda, California;
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Eugene W. Liu
eliu@llu.edu
Eugene W. Liu
Loma Linda University School of Medicine, Loma Linda, California;
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ABSTRACT.
Data on the burden of extended-spectrum β-lactamase producing Enterobacterales are limited in Jamaica. This study aims to identify factors associated with the isolation of ceftriaxone-resistant Enterobacterales in patients at a private hospital in Jamaica through a retrospective case–control study comparing patients with and without ceftriaxone-resistant Enterobacterales in 2021. The case subjects had at least one Enterobacterales isolate resistant to ceftriaxone, and the controls had at least one culture, all without cephalosporin resistance, including those without growth. The data extracted included antibiotics received, organism, sex, and age. Older age, male sex, and the isolation of Enterobacter species were independently associated with increased odds of ceftriaxone-resistant Enterobacterales on logistic regression. Age and male sex may be markers for past exposure to β-lactam antibiotics or nosocomial infection with ceftriaxone-resistant Enterobacterales and may have a greater influence on isolation of ceftriaxone-resistant Enterobacterales compared with the receipt of antibiotics in the past six months, with which no association was observed on final analysis.
Author Notes
Financial support: This work was supported by the
Disclosures: This study was approved by the LLUH and AMH Institutional Review Boards (IRB #: 5220074), with an exempt determination indicating that consent was not required, wherein the use of protected health information involves no more than minimal risk to the privacy of individuals and could not practically be conducted without a waiver and the use of protected health information.
Current contact information: Matthew S. Mendoza and Eugene W. Liu, Loma Linda University School of Medicine, Loma Linda, CA, E-mails: matthewmendoza@students.llu.edu and eliu@llu.edu. Fredricka A. Coombs, Andrews Memorial Hospital, Kingston, Jamaica, E-mail: fcoombs@amhosp.org. Hansel M. Fletcher, Division of Microbiology and Molecular Genetics, Loma Linda University School of Medicine, Loma Linda, CA, E-mail: hfletcher@llu.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Antimicrobial Resistance Collaborators, 2022. Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Lancet 399: 629–655.
-
2.
Jernigan JA et al., 2020. Multidrug-resistant bacterial infections in U.S. hospitalized patients, 2012–2017. N Engl J Med 382: 1309–1319.
-
3.
Goodman KE, Lessler J, Cosgrove SE, Harris AD, Lautenbach E, Han JH, Milstone AM, Massey CJ, Tamma PD; Antibacterial Resistance Leadership Group, 2016. A clinical decision tree to predict whether a bacteremic patient is infected with an extended-spectrum β-lactamase-producing organism. Clin Infect Dis 63: 896–903.
-
4.
Park YS, Adams-Haduch JM, Shutt KA, Yarabinec DM, Johnson LE, Hingwe A, Lewis JS, Jorgensen JH, Doi Y, 2012. Clinical and microbiologic characteristics of cephalosporin-resistant Escherichia coli at three centers in the United States. Antimicrob Agents Chemother 56: 1870–1876.
-
5.
Liu EW, Buss SN, Trumbo JL, Temples TM, 2021. Clinical and demographic features associated with infections with extended-spectrum beta-lactamase-producing Escherichia coli in a health system in Maine, 2017. Antimicrob Steward Healthc Epidemiol 1: e7.
-
6.
Christian NA, Roye-Green K, Smikle M, 2010. Molecular epidemiology of multidrug resistant extended spectrum beta-lactamase producing Klebsiella pneumoniae at a Jamaican hospital, 2000–2004. BMC Microbiol 10: 27.
-
7.
Nicholson AM, Ledgister S, Williams T, Robinson S, Gayle P, Lindo T, Castle D, Shaw K, Moonah S, 2009. Distribution of nosocomial organisms and their resistance patterns in the intensive care unit of the University Hospital of the West Indies, Kingston, Jamaica. West Indian Med J 58: 142–148. PubMed PMID: WOS:000269356800013.
-
8.
Thoms-Rodriguez C-A, Mazzulli T, Christian N, Willey BM, Boyd DA, Mataseje LF, Mulvey MR, Christie CDC, Nicholson AM, 2016. New Delhi metallo-β-lactamase in Jamaica. J Infect Dev Ctries 10: 183–187.
-
9.
Kang C-I, Wi YM, Lee MY, Ko KS, Chung DR, Peck KR, Lee NY, Song J-H, 2012. Epidemiology and risk factors of community onset infections caused by extended-spectrum β-lactamase-producing Escherichia coli strains. J Clin Microbiol 50: 312–317.
-
10.
Rodríguez‐Baño J et al., 2010. Community-onset bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli: Risk factors and prognosis. Clin Infect Dis 50: 40–48.
-
11.
Sogaard M, Heide-Jorgensen U, Vandenbroucke JP, Schonheyder HC, Vandenbroucke-Grauls C, 2017. Risk factors for extended-spectrum β-lactamase-producing Escherichia coli urinary tract infection in the community in Denmark: A case-control study. Clin Microbiol Infect 23: 952–960.
-
12.
World Bank Rural Population (% of total population): The World Bank, 2020. Available at: https://data.worldbank.org/indicator/SP.RUR.TOTL.ZS?locations=JM. Accessed May 24, 2024.
-
13.
Obeng-Nkrumah N, Twum-Danso K, Krogfelt KA, Newman MJ, 2013. High levels of extended-spectrum beta-lactamases in a major teaching hospital in Ghana: The need for regular monitoring and evaluation of antibiotic resistance. Am J Trop Med Hyg 89: 960–964.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 9312 | 9312 | 2487 |
| Full Text Views | 42 | 42 | 14 |
| PDF Downloads | 40 | 40 | 18 |