Author:
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1.
Kumar M, Krishnamurthy S, Delhikumar CG, Narayanan P, Biswal N, Srinivasan S, 2012. Scrub typhus in children at a tertiary hospital in southern India: Clinical profile and complications. J Infect Public Health 5: 82–88.
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2.
Nallasamy K, Gupta S, Bansal A, Biswal M, Jayashree M, Zaman K, Williams V, Kumar A, 2020. Clinical profile and predictors of intensive care unit admission in pediatric scrub typhus: A retrospective observational study from North India. Indian J Crit Care Med 24: 445–450.
-
3.
Alkathiry HA, Alghamdi SQ, Sinha A, Margos G, Stekolnikov AA, Alagaili AN, Darby AC, Makepeace BL, Khoo JJ, 2023. Molecular detection of candidatus orientia chuto in wildlife, Saudi Arabia. Emerg Infect Dis 29: 402–406.
-
4.
Abarca K, Martínez-Valdebenito C, Angulo J, Jiang J, Farris CM, Richards AL, Acosta-Jamett G, Weitzel T, 2020. Molecular description of a novel orientia species causing scrub typhus in Chile. Emerg Infect Dis 26: 2148–2156.
-
5.
Izzard L et al., 2010. Isolation of a novel Orientia species (O. chuto sp. nov.) from a patient infected in Dubai. J Clin Microbiol 48: 4404–4409.
-
6.
Parajuli B, Angurana SK, Awasthi P, Nallasamy K, Baranwal A, Bansal A, Bansal D, Rawat A, Varma N, Jayashree M, 2021. Hemophagocytic lymphohistiocytosis in a PICU of a developing economy: Clinical profile, intensive care needs, outcome, and predictors of mortality. Pediatr Crit Care Med 22: e44–e57.
-
7.
Rai TK, Chakravarty J, Kashyap S, Chatterjee S, Tiwari VD, Rai UG, Gangwar M, Sundar S, Nath G, 2024. Etiology of acute encephalitis syndrome in adults in a tertiary care center in Eastern Uttar Pradesh. Am J Trop Med Hyg 112: 194–199.
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8.
Singh J, Dinkar A, Kumar N, Kumar K, Tejan N, 2024. Digital gangrene associated with scrub typhus: A case series. Am J Trop Med Hyg 110: 497–500.
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9.
Saini V, Irfan Khan S, Vincent A, Singh N, Kuniabdullah S, 2024. Various presentations of scrub typhus: A case series. Cureus 16: e64981.
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10.
Prasannan A, Ramaswamy P, Anirudhan VK, 2017. Rickettsial fever presenting with gangrene: A case series. J Clin Diagn Res 11: PR01–PR3.
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11.
Dash N, Gonttumukkula V, Samyanathan P, Rajangam M, Biswal M, Verma S, 2023. Indian tick typhus presenting as gangrene: A case report. Pediatr Infect Dis J 42: e249–e250.
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12.
Chaudhary H, Mohan M, Jain A, Kumar V, Takia L, Sudhakar M, Angurana SK, Jindal AK, 2021. Acral gangrene: Ugly cousin of “COVID toes” in multisystem inflammatory syndrome in children associated with SARS-CoV-2? Pediatr Infect Dis J 40: e312–e313.
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13.
Sundaram V, Suthar R, Kumar S, Saini L, Subramanu V, Pilania R, 2021. Peripheral limb gangrene in neonates. J Postgrad Med Edu and Res 55: 177–179.
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14.
Alhumam T, Alhumam AA, Alhumaidi I, Al Rajeh I, Alduhailan Y, 2024. Relationship between symmetrical peripheral gangrene patients and using vasopressors in the intensive care unit. Cureus 16: e58117.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1373 | 1373 | 677 |
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Symmetrical Peripheral Gangrene in an Indian Child with Severe Scrub Typhus
Prasanna Samynathan
Prasanna Samynathan
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India;
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Neha Sharma
Neha Sharma
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India;
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Priyanka Meena
Priyanka Meena
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India;
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Manisha Biswal
Manisha Biswal
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Suresh Kumar Angurana
sureshangurana@gmail.com
Suresh Kumar Angurana
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India;
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ABSTRACT.
Scrub typhus is one of the common causes for acute febrile illness in monsoon and post-monsoon season in our region. It usually presents as fever, rash, and thrombocytopenia with or without multiorgan dysfunction syndrome (MODS). Infrequently, it can cause focal or symmetrical peripheral gangrene (SPG). Here, we report a 5-year-old female who presented with acute febrile illness with MODS and SPG in bilateral lower limbs. The diagnosis of scrub typhus was confirmed with positive scrub typhus IgM antibodies. She recovered completely after combination therapy with doxycycline and azithromycin, and organ supportive therapy (mechanical ventilation, vasoactive drugs, and continuous renal replacement therapy) in the pediatric intensive care unit.
Author Notes
Current contact information: Prasanna Samynathan, Neha Sharma, Priyanka Meena, and Suresh Kumar Angurana, Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India, E-mails: samyannampras@gmail.com, and sharma.nehasharma062@gmail.com. Manisha Biswal, Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, E-mail: manisha.biswal@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Kumar M, Krishnamurthy S, Delhikumar CG, Narayanan P, Biswal N, Srinivasan S, 2012. Scrub typhus in children at a tertiary hospital in southern India: Clinical profile and complications. J Infect Public Health 5: 82–88.
-
2.
Nallasamy K, Gupta S, Bansal A, Biswal M, Jayashree M, Zaman K, Williams V, Kumar A, 2020. Clinical profile and predictors of intensive care unit admission in pediatric scrub typhus: A retrospective observational study from North India. Indian J Crit Care Med 24: 445–450.
-
3.
Alkathiry HA, Alghamdi SQ, Sinha A, Margos G, Stekolnikov AA, Alagaili AN, Darby AC, Makepeace BL, Khoo JJ, 2023. Molecular detection of candidatus orientia chuto in wildlife, Saudi Arabia. Emerg Infect Dis 29: 402–406.
-
4.
Abarca K, Martínez-Valdebenito C, Angulo J, Jiang J, Farris CM, Richards AL, Acosta-Jamett G, Weitzel T, 2020. Molecular description of a novel orientia species causing scrub typhus in Chile. Emerg Infect Dis 26: 2148–2156.
-
5.
Izzard L et al., 2010. Isolation of a novel Orientia species (O. chuto sp. nov.) from a patient infected in Dubai. J Clin Microbiol 48: 4404–4409.
-
6.
Parajuli B, Angurana SK, Awasthi P, Nallasamy K, Baranwal A, Bansal A, Bansal D, Rawat A, Varma N, Jayashree M, 2021. Hemophagocytic lymphohistiocytosis in a PICU of a developing economy: Clinical profile, intensive care needs, outcome, and predictors of mortality. Pediatr Crit Care Med 22: e44–e57.
-
7.
Rai TK, Chakravarty J, Kashyap S, Chatterjee S, Tiwari VD, Rai UG, Gangwar M, Sundar S, Nath G, 2024. Etiology of acute encephalitis syndrome in adults in a tertiary care center in Eastern Uttar Pradesh. Am J Trop Med Hyg 112: 194–199.
-
8.
Singh J, Dinkar A, Kumar N, Kumar K, Tejan N, 2024. Digital gangrene associated with scrub typhus: A case series. Am J Trop Med Hyg 110: 497–500.
-
9.
Saini V, Irfan Khan S, Vincent A, Singh N, Kuniabdullah S, 2024. Various presentations of scrub typhus: A case series. Cureus 16: e64981.
-
10.
Prasannan A, Ramaswamy P, Anirudhan VK, 2017. Rickettsial fever presenting with gangrene: A case series. J Clin Diagn Res 11: PR01–PR3.
-
11.
Dash N, Gonttumukkula V, Samyanathan P, Rajangam M, Biswal M, Verma S, 2023. Indian tick typhus presenting as gangrene: A case report. Pediatr Infect Dis J 42: e249–e250.
-
12.
Chaudhary H, Mohan M, Jain A, Kumar V, Takia L, Sudhakar M, Angurana SK, Jindal AK, 2021. Acral gangrene: Ugly cousin of “COVID toes” in multisystem inflammatory syndrome in children associated with SARS-CoV-2? Pediatr Infect Dis J 40: e312–e313.
-
13.
Sundaram V, Suthar R, Kumar S, Saini L, Subramanu V, Pilania R, 2021. Peripheral limb gangrene in neonates. J Postgrad Med Edu and Res 55: 177–179.
-
14.
Alhumam T, Alhumam AA, Alhumaidi I, Al Rajeh I, Alduhailan Y, 2024. Relationship between symmetrical peripheral gangrene patients and using vasopressors in the intensive care unit. Cureus 16: e58117.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1373 | 1373 | 677 |
| Full Text Views | 23 | 23 | 9 |
| PDF Downloads | 31 | 31 | 15 |