Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2024. Global Tuberculosis Report 2023. Available at: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023. Accessed February 11, 2024.
-
2.
Sample Registration System, 2023. Cause of Death Statistics 2017-19. Available at: https://censusindia.gov.in/nada/index.php/catalog/44752. Accessed February 12, 2025.
-
3.
World Health Organization 2019. Global Tuberculosis Report 2018. Available at: https://iris.who.int/bitstream/handle/10665/274453/9789241565646-eng.pd. Accessed August 24, 2024.
-
4.
Central Tuberculosis Division, India, 2020. National Strategic Plan for Tuberculosis Elimination 2017–2025. Available at: https://tbcindia.gov.in/WriteReadData/NSP%20Draft%2020.02.2017%201.pdf/. Accessed August 15, 2020.
-
5.
Pradeepa R, Mohan V, 2021. Epidemiology of type 2 diabetes in India. Indian J Ophthalmol 69: 2932–2938.
-
6.
Jeon CY, Murray MB, 2008. Diabetes mellitus increases the risk of active tuberculosis: A systematic review of 13 observational studies. PLoS Med 5: e152.
-
7.
Lee PH, Fu H, Lai TC, Chiang CY, Chan CC, Lin HH, 2016. Glycemic control and the risk of tuberculosis: A cohort study. PLoS Med 13: e1002072.
-
8.
Pan SC, Ku CC, Kao D, Ezzati M, Fang CT, Lin HH, 2015. Effect of diabetes on tuberculosis control in 13 countries with high tuberculosis: A modelling study. Lancet Diabetes Endocrinol 3: 323–330.
-
9.
Baker MA, Harries AD, Jeon CY, Hart JE, Kapur A, Lönnroth K, Ottmani SE, Goonesekera SD, Murray MB, 2011. The impact of diabetes on tuberculosis treatment outcomes: A systematic review. BMC Med 9: 81.
-
10.
Dooley KE, Tang T, Golub JE, Dorman SE, Cronin W, 2009. Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis. Am J Trop Med Hyg 80: 634–639.
-
11.
Siddiqui AN, Khayyam KU, Sharma M, 2016. Effect of diabetes mellitus on tuberculosis treatment outcome and adverse reactions in patients receiving directly observed treatment strategy in India: A prospective study. Biomed Res Int 2016: 7273935.
-
12.
K V N, Duraisamy K, Balakrishnan S, M S, S JS, Sagili KD, Satyanarayana S, M V AK, Enarson DA, 2013. Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram district, Kerala, India. PLoS One 8: e76275.
-
13.
Shewade HD, Jeyashree K, Mahajan P, Shah AN, Kirubakaran R, Rao R, Kumar AMV, 2017. Effect of glycemic control and type of diabetes treatment on unsuccessful TB treatment outcomes among people with TB-Diabetes: A systematic review. PLoS One 12: e0186697.
-
14.
Yoon YS et al., 2017. The effect of diabetes control status on treatment response in pulmonary tuberculosis: A prospective study. Thorax 72: 263–270.
-
15.
World Health Organization, 2020. Definitions and Reporting Framework for Tuberculosis—2013 Revision: Updated December 2014 and January 2020. Available at: https://www.who.int/publications-detail-redirect/9789241505345. Accessed August 13, 2020.
-
16.
Vyas S, Kumaranayake L, 2006. Constructing socio-economic status indices: How to use principal components analysis. Health Policy Plan 21: 459–468.
-
17.
Huangfu P, Ugarte-Gil C, Golub J, Pearson F, Critchley J, 2019. The effects of diabetes on tuberculosis treatment outcomes: An updated systematic review and meta-analysis. Int J Tuberc Lung Dis 23: 783–796.
-
18.
Yoo JE, Kim D, Han K, Rhee SY, Shin DW, Lee H, 2021. Diabetes status and association with risk of tuberculosis among Korean adults. JAMA Netw Open 4: e2126099.
-
19.
Buasroung P, Petnak T, Liwtanakitpipat P, Kiertiburanakul S, 2022. Prevalence of diabetes mellitus in patients with tuberculosis: A prospective cohort study. Int J Infect Dis 116: 374–379.
-
20.
Paralija B, Zutic H, 2012. Clinical features of pulmonary tuberculosis in patients with diabetes mellitus. Eur Respir J 40 (Suppl 56).
-
21.
Gil-Santana L, Almeida-Junior JL, Oliveira CA, Hickson LS, Daltro C, Castro S, Kornfeld H, Netto EM, Andrade BB, 2016. Diabetes is associated with worse clinical presentation in tuberculosis patients from Brazil: A retrospective cohort study. PLoS One 11: e0146876.
-
22.
Alisjahbana B, Sahiratmadja E, Nelwan EJ, Purwa AM, Ahmad Y, Ottenhoff TH, Nelwan RH, Parwati I, van der Meer JW, van Crevel R, 2007. The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis. Clin Infect Dis 45: 428–435.
-
23.
Gautam S, Shrestha N, Mahato S, Nguyen TPA, Mishra SR, Berg-Beckhoff G, 2021. Diabetes among tuberculosis patients and its impact on tuberculosis treatment in South Asia: A systematic review and meta-analysis. Sci Rep 11: 2113.
-
24.
Mave V et al., 2021. Diabetes mellitus and tuberculosis treatment outcomes in Pune, India. Open Forum Infect Dis 8: ofab097.
-
25.
Nguyen DT, Graviss EA, 2019. Diabetic trends and associated mortality in tuberculosis patients in Texas, a large population-based analysis. Tuberculosis (Edinb) 116S: S59–S65.
-
26.
Murali S, Krishnamoorthy Y, Knudsen S, Roy G, Ellner J, Horsburgh CR, Hochberg N, Salgame P, Prakash Babu S, Sarkar S, 2021. Comparison of profile and treatment outcomes between elderly and non-elderly tuberculosis patients in Puducherry and Tamil Nadu, South India. PLoS One 16: e0256773.
-
27.
Bhargava A et al., 2023. Nutritional support for adult patients with microbiologically confirmed pulmonary tuberculosis: Outcomes in a programmatic cohort nested within the RATIONS trial in Jharkhand, India. Lancet Glob Health 11: e1402–e1411.
-
28.
Caraux-Paz P, Diamantis S, de Wazières B, Gallien S, 2021. Tuberculosis in the elderly. J Clin Med 10: 5888.
-
29.
Faurholt-Jepsen D et al., 2012. The role of diabetes co-morbidity for tuberculosis treatment outcomes: A prospective cohort study from Mwanza, Tanzania. BMC Infect Dis 12: 165.
-
30.
Zheng Y, Ma A, Wang Q, Han X, Cai J, Schouten EG, Kok FJ, Li Y, 2013. Relation of leptin, ghrelin and inflammatory cytokines with body mass index in pulmonary tuberculosis patients with and without type 2 diabetes mellitus. PLoS One 8: e80122.
-
31.
Haddad F, Dokmak G, Bader M, Karaman R, 2023. A comprehensive review on weight loss associated with anti-diabetic medications. Life (Basel) 13: 1012.
-
32.
World Health Organization, 2011. Collaborative Framework for Care and Control of Tuberculosis and Diabetes. Geneva, Switzerland: WHO.
-
33.
Bisht MK, Dahiya P, Ghosh S, Mukhopadhyay S, 2023. The cause–effect relation of tuberculosis on incidence of diabetes mellitus. Front Cell Infect Microbiol 13: 1134036.
-
34.
van Crevel R, Critchley JA, 2021. The interaction of diabetes and tuberculosis: Translating research to policy and practice. Trop Med Infect Dis 6: 8.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 22059 | 22059 | 9758 |
| Full Text Views | 71 | 71 | 23 |
| PDF Downloads | 42 | 42 | 11 |
Association of Diabetes Mellitus with Presentation and Treatment Outcomes among Adult Patients with Pulmonary Tuberculosis
Rakesh Kumar
dr.rakesh3105@gmail.com
Rakesh Kumar
Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India;
Search for other papers by Rakesh Kumar in
Current site
Google Scholar
PubMed
Search for other papers by Rakesh Kumar in
Current site
Google Scholar
PubMed
Urvashi B Singh
Urvashi B Singh
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India;
Search for other papers by Urvashi B Singh in
Current site
Google Scholar
PubMed
Search for other papers by Urvashi B Singh in
Current site
Google Scholar
PubMed
Ankit Chandra
Ankit Chandra
Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India;
Search for other papers by Ankit Chandra in
Current site
Google Scholar
PubMed
Search for other papers by Ankit Chandra in
Current site
Google Scholar
PubMed
Devasenathipathy Kandasamy
Devasenathipathy Kandasamy
Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India
Search for other papers by Devasenathipathy Kandasamy in
Current site
Google Scholar
PubMed
Search for other papers by Devasenathipathy Kandasamy in
Current site
Google Scholar
PubMed
Anand Krishnan
Anand Krishnan
Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India;
Search for other papers by Anand Krishnan in
Current site
Google Scholar
PubMed
Search for other papers by Anand Krishnan in
Current site
Google Scholar
PubMed
ABSTRACT.
This prospective study was done to compare the initial presentation and treatment outcomes of tuberculosis among adult patients who have diabetes mellitus with those without diabetes mellitus. In this study, all adult patients (age 18 years old or older) with microbiologically confirmed drug-sensitive pulmonary tuberculosis who were put on treatment in Ballabgarh block in Haryana were enrolled. Information on clinical, radiological, and microbiological parameters at baseline was obtained by interview or record review. Symptom score was calculated by assigning one point for each symptom from zero to seven. Patients were followed for 6 months from the start of treatment to assess treatment outcomes. Data were analyzed using the χ2 or Fisher exact test. Logistic regression was used to assess the factors associated with death or unfavorable outcomes. In total, 412 patients were included in the study, of which 17.5% had diabetes mellitus. The mean symptom scores among those with and without diabetes were 3.7 (SD 1.3) and 3.6 (SD 1.4), respectively. Treatment success was achieved in 83.6% of patients with diabetes and 86.4% of patients without diabetes. Death was observed in 12.3% of patients with diabetes compared with 7.1% of patients without diabetes. There was no significant difference in clinical presentation, radiology, or sputum smear grade at baseline between patients with or without diabetes. Although treatment success rate was less and death rate was higher in patients with tuberculosis who had diabetes compared with those who did not have diabetes, the difference was not statistically significant.
- Supplemental Materials (PDF 307.65 KB)
Author Notes
Disclosures: Written informed consent was taken from all of the patients enrolled. Ethical approval for the study was obtained from the Institute Ethics Committee of the All India Institute of Medical Sciences, New Delhi. Data are available on request from the corresponding author.
Author’s contributions: R. Kumar, D. Kandasamy, and A. Krishnan were responsible for the concept and study design. R. Kumar, U. Singh, A. Chandra, and D. Kandasamy did the study implementation. R. Kumar, U. Singh, A. Chandra, D. Kandasamy, and A. Krishnan did the data analysis, interpreted results, critically reviewed, and approved the manuscript.
Current contact information: Rakesh Kumar, Ankit Chandra, and Anand Krishnan, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India, E-mails: dr.rakesh3105@gmail.com, suniyal3151@gmail.com, and anand.drk@gmail.com. Urvashi B Singh, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India, E-mail: drurvashi@gmail.com. Devasenathipathy Kandasamy, Department of Radiology, All India Institute of Medical Sciences, New Delhi, India, E-mail: devammc@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2024. Global Tuberculosis Report 2023. Available at: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023. Accessed February 11, 2024.
-
2.
Sample Registration System, 2023. Cause of Death Statistics 2017-19. Available at: https://censusindia.gov.in/nada/index.php/catalog/44752. Accessed February 12, 2025.
-
3.
World Health Organization 2019. Global Tuberculosis Report 2018. Available at: https://iris.who.int/bitstream/handle/10665/274453/9789241565646-eng.pd. Accessed August 24, 2024.
-
4.
Central Tuberculosis Division, India, 2020. National Strategic Plan for Tuberculosis Elimination 2017–2025. Available at: https://tbcindia.gov.in/WriteReadData/NSP%20Draft%2020.02.2017%201.pdf/. Accessed August 15, 2020.
-
5.
Pradeepa R, Mohan V, 2021. Epidemiology of type 2 diabetes in India. Indian J Ophthalmol 69: 2932–2938.
-
6.
Jeon CY, Murray MB, 2008. Diabetes mellitus increases the risk of active tuberculosis: A systematic review of 13 observational studies. PLoS Med 5: e152.
-
7.
Lee PH, Fu H, Lai TC, Chiang CY, Chan CC, Lin HH, 2016. Glycemic control and the risk of tuberculosis: A cohort study. PLoS Med 13: e1002072.
-
8.
Pan SC, Ku CC, Kao D, Ezzati M, Fang CT, Lin HH, 2015. Effect of diabetes on tuberculosis control in 13 countries with high tuberculosis: A modelling study. Lancet Diabetes Endocrinol 3: 323–330.
-
9.
Baker MA, Harries AD, Jeon CY, Hart JE, Kapur A, Lönnroth K, Ottmani SE, Goonesekera SD, Murray MB, 2011. The impact of diabetes on tuberculosis treatment outcomes: A systematic review. BMC Med 9: 81.
-
10.
Dooley KE, Tang T, Golub JE, Dorman SE, Cronin W, 2009. Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis. Am J Trop Med Hyg 80: 634–639.
-
11.
Siddiqui AN, Khayyam KU, Sharma M, 2016. Effect of diabetes mellitus on tuberculosis treatment outcome and adverse reactions in patients receiving directly observed treatment strategy in India: A prospective study. Biomed Res Int 2016: 7273935.
-
12.
K V N, Duraisamy K, Balakrishnan S, M S, S JS, Sagili KD, Satyanarayana S, M V AK, Enarson DA, 2013. Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram district, Kerala, India. PLoS One 8: e76275.
-
13.
Shewade HD, Jeyashree K, Mahajan P, Shah AN, Kirubakaran R, Rao R, Kumar AMV, 2017. Effect of glycemic control and type of diabetes treatment on unsuccessful TB treatment outcomes among people with TB-Diabetes: A systematic review. PLoS One 12: e0186697.
-
14.
Yoon YS et al., 2017. The effect of diabetes control status on treatment response in pulmonary tuberculosis: A prospective study. Thorax 72: 263–270.
-
15.
World Health Organization, 2020. Definitions and Reporting Framework for Tuberculosis—2013 Revision: Updated December 2014 and January 2020. Available at: https://www.who.int/publications-detail-redirect/9789241505345. Accessed August 13, 2020.
-
16.
Vyas S, Kumaranayake L, 2006. Constructing socio-economic status indices: How to use principal components analysis. Health Policy Plan 21: 459–468.
-
17.
Huangfu P, Ugarte-Gil C, Golub J, Pearson F, Critchley J, 2019. The effects of diabetes on tuberculosis treatment outcomes: An updated systematic review and meta-analysis. Int J Tuberc Lung Dis 23: 783–796.
-
18.
Yoo JE, Kim D, Han K, Rhee SY, Shin DW, Lee H, 2021. Diabetes status and association with risk of tuberculosis among Korean adults. JAMA Netw Open 4: e2126099.
-
19.
Buasroung P, Petnak T, Liwtanakitpipat P, Kiertiburanakul S, 2022. Prevalence of diabetes mellitus in patients with tuberculosis: A prospective cohort study. Int J Infect Dis 116: 374–379.
-
20.
Paralija B, Zutic H, 2012. Clinical features of pulmonary tuberculosis in patients with diabetes mellitus. Eur Respir J 40 (Suppl 56).
-
21.
Gil-Santana L, Almeida-Junior JL, Oliveira CA, Hickson LS, Daltro C, Castro S, Kornfeld H, Netto EM, Andrade BB, 2016. Diabetes is associated with worse clinical presentation in tuberculosis patients from Brazil: A retrospective cohort study. PLoS One 11: e0146876.
-
22.
Alisjahbana B, Sahiratmadja E, Nelwan EJ, Purwa AM, Ahmad Y, Ottenhoff TH, Nelwan RH, Parwati I, van der Meer JW, van Crevel R, 2007. The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis. Clin Infect Dis 45: 428–435.
-
23.
Gautam S, Shrestha N, Mahato S, Nguyen TPA, Mishra SR, Berg-Beckhoff G, 2021. Diabetes among tuberculosis patients and its impact on tuberculosis treatment in South Asia: A systematic review and meta-analysis. Sci Rep 11: 2113.
-
24.
Mave V et al., 2021. Diabetes mellitus and tuberculosis treatment outcomes in Pune, India. Open Forum Infect Dis 8: ofab097.
-
25.
Nguyen DT, Graviss EA, 2019. Diabetic trends and associated mortality in tuberculosis patients in Texas, a large population-based analysis. Tuberculosis (Edinb) 116S: S59–S65.
-
26.
Murali S, Krishnamoorthy Y, Knudsen S, Roy G, Ellner J, Horsburgh CR, Hochberg N, Salgame P, Prakash Babu S, Sarkar S, 2021. Comparison of profile and treatment outcomes between elderly and non-elderly tuberculosis patients in Puducherry and Tamil Nadu, South India. PLoS One 16: e0256773.
-
27.
Bhargava A et al., 2023. Nutritional support for adult patients with microbiologically confirmed pulmonary tuberculosis: Outcomes in a programmatic cohort nested within the RATIONS trial in Jharkhand, India. Lancet Glob Health 11: e1402–e1411.
-
28.
Caraux-Paz P, Diamantis S, de Wazières B, Gallien S, 2021. Tuberculosis in the elderly. J Clin Med 10: 5888.
-
29.
Faurholt-Jepsen D et al., 2012. The role of diabetes co-morbidity for tuberculosis treatment outcomes: A prospective cohort study from Mwanza, Tanzania. BMC Infect Dis 12: 165.
-
30.
Zheng Y, Ma A, Wang Q, Han X, Cai J, Schouten EG, Kok FJ, Li Y, 2013. Relation of leptin, ghrelin and inflammatory cytokines with body mass index in pulmonary tuberculosis patients with and without type 2 diabetes mellitus. PLoS One 8: e80122.
-
31.
Haddad F, Dokmak G, Bader M, Karaman R, 2023. A comprehensive review on weight loss associated with anti-diabetic medications. Life (Basel) 13: 1012.
-
32.
World Health Organization, 2011. Collaborative Framework for Care and Control of Tuberculosis and Diabetes. Geneva, Switzerland: WHO.
-
33.
Bisht MK, Dahiya P, Ghosh S, Mukhopadhyay S, 2023. The cause–effect relation of tuberculosis on incidence of diabetes mellitus. Front Cell Infect Microbiol 13: 1134036.
-
34.
van Crevel R, Critchley JA, 2021. The interaction of diabetes and tuberculosis: Translating research to policy and practice. Trop Med Infect Dis 6: 8.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 22059 | 22059 | 9758 |
| Full Text Views | 71 | 71 | 23 |
| PDF Downloads | 42 | 42 | 11 |