Author:
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-
1.
Kumar A, Pandey A, Singh AK, Dubey A, Singh A, Gaur V, 2022. The current epidemiology of rotavirus infection in children less than 5 years of age after introduction of RV vaccine in India.J Pure Appl Microbiol 16: 471–480.
-
2.
Iturriza-Gómara M, Kang G, Gray J, 2004. Rotavirus genotyping: Keeping up with an evolving population of human rotaviruses.J Clin Virol 31: 259–265.
-
3.
Santos N, Hoshino Y, 2005. Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine.Rev Med Virol 15: 29–56.
-
4.
Crawford SE et al., 2017. Rotavirus infection.Nat Rev Dis Primers 3: 17083.
-
5.
Lestari FB, Vongpunsawad S, Wanlapakorn N, Poovorawan Y, 2020. Rotavirus infection in children in Southeast Asia 2008–2018: Disease burden, genotype distribution, seasonality, and vaccination.J Biomed Sci 27: 66.
-
6.
Ansari SA, Springthorpe VS, Sattar SA, 1991. Survival and vehicular spread of human rotaviruses: Possible relation to seasonality of outbreaks. Rev Infect Dis 13: 448–461.
-
7.
Estes MK, Cohen J, 1989. Rotavirus gene structure and function.Microbiol Rev 53: 410–449.
-
8.
Greenberg HB, Estes MK, 2009. Rotaviruses: From pathogenesis to vaccination. Gastroenterology 136: 1939–1951.
-
9.
World Health Organization, 2007. Rotavirus vaccines. Wkly Epidemiol Rec 82: 285–295.
-
10.
Hung T, Chen GM, Wang CG, 1983. Rotavirus-like agent in adult non-bacterial diarrhea in China. Lancet 5: 1078–1079.
-
11.
Sen A, Kobayashi N, Das S, Krishnan T, Bhattacharya SK, Naik TN, 2001. The evolution of human group B rotaviruses. Lancet 357: 198–199.
-
12.
Kuzuya M, Fujii R, Hamano M, Ohata R, Ogura H, Yamada M, 2001. Seroepidemiology of human group C rotavirus in Japan based on a blocking enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol 8: 161–165.
-
13.
Riepenhoff-Talty M, Morse K, Wang CH, Shapiro C, Roberts J, Welter M, Allen M, Evans MJ, Flanagan TD, 1997. Epidemiology of group C rotavirus infection in Western New York women of childbearing age.J Clin Microbiol 35: 486–488.
-
14.
Hall AJ, Lopman BA, Payne DC, Patel MM, Gastañaduy PA, Vinjé J, Parashar UD, 2013. Norovirus disease in the United States.Emerg Infect Dis 19: 1198–1205.
-
15.
Lopman B, Gastañaduy P, Park GW, Hall AJ, Parashar UD, Vinjé J, 2012. Environmental transmission of norovirus gastroenteritis.Curr Opin Virol 2: 96–102.
-
16.
Iturriza Gómara M, Wong C, Blome S, Desselberger U, Gray J, 2002. Molecular characterization of VP6 genes of human rotavirus isolates: Correlation of genogroups with subgroups and evidence of independent segregation.J Virol 76: 6596–6601.
-
17.
Lin YP, Kao CL, Chang SY, Taniguchi K, Hung PY, Lin HC, Huang LM, Huang HH, Yang JY, Lee CN, 2008. Determination of human rotavirus VP6 genogroups I and II by reverse transcription-PCR.J Clin Microbiol 46: 3330–3337.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 542 | 542 | 200 |
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Rotavirus Infection in Children Suffering from Diarrhea in Patna, Bihar Region, India: A Hospital-Based Study
Neetesh Jindal
Neetesh Jindal
Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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Ashish Kumar
Ashish Kumar
Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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Ashiq Hussain Bhat
Ashiq Hussain Bhat
Department of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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Major Madhukar
Major Madhukar
Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India
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Roshan Kamal Topno
Roshan Kamal Topno
Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India
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Krishna Pandey
Krishna Pandey
Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India
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Ganesh Chandra Sahoo
ganeshiitkgp@gmail.com
Ganesh Chandra Sahoo
Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India;
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ABSTRACT.
Rotavirus (RV) is a leading cause of severe gastroenteritis in infants and young children, often resulting in dehydration and hospitalization. Although global data on RV is well-documented, there is limited information on its prevalence and genetic diversity in Bihar, India. This study aimed to investigate the prevalence of RV infections in the patient, from January 2021 to June 2024, and assess the associated molecular and epidemiological patterns. In this retrospective study conducted at the Rajendra Memorial Research Institute of Medical Sciences, Patna, 1,820 stool samples from patients suspected of RV infection were collected. Enzyme immunoassays were used to detect RV antigens, and positive samples were confirmed by real-time polymerase chain reaction targeting the VP4, VP6, and VP7 genes. Phylogenetic analysis was performed to examine genetic diversity. Results showed a 10% positivity rate for RV, with 5% showing equivocal results. The highest prevalence was in the 6–11 years age group (72 positive cases), followed by the 0–5 years group (62 positive cases). Prevalence decreased in older age groups, suggesting immunity through natural infection or vaccination. Phylogenetic analysis revealed distinct regional clusters and genetic variability between strains from Bihar and other parts of India, such as New Delhi and Kolkata. This study provides valuable baseline data on RV prevalence and genetic diversity in Bihar, emphasizing the need for vaccination and surveillance, particularly for younger children at higher risk. The observed genetic diversity suggests regional variations, highlighting the importance of continuous surveillance across India.
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Author Notes
Current contact information: Neetesh Jindal, Ashish Kumar, Major Madhukar, and Ganesh Chandra Sahoo, Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India, E-mails: jindalneetesh@gmail.com, ashish2k8@gmail.com, madhukarcaptpatna@gmail.com, and ganeshiitkgp@gmail.com. Ashiq Hussain Bhat, Department of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India, E-mail: ashiqhb14@gmail.com. Roshan Kamal Topno and Krishna Pandey, Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India, E-mails: roshanktopno@yahoo.co.in and pandey.krishna@icmr.gov.in
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Kumar A, Pandey A, Singh AK, Dubey A, Singh A, Gaur V, 2022. The current epidemiology of rotavirus infection in children less than 5 years of age after introduction of RV vaccine in India.J Pure Appl Microbiol 16: 471–480.
-
2.
Iturriza-Gómara M, Kang G, Gray J, 2004. Rotavirus genotyping: Keeping up with an evolving population of human rotaviruses.J Clin Virol 31: 259–265.
-
3.
Santos N, Hoshino Y, 2005. Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine.Rev Med Virol 15: 29–56.
-
4.
Crawford SE et al., 2017. Rotavirus infection.Nat Rev Dis Primers 3: 17083.
-
5.
Lestari FB, Vongpunsawad S, Wanlapakorn N, Poovorawan Y, 2020. Rotavirus infection in children in Southeast Asia 2008–2018: Disease burden, genotype distribution, seasonality, and vaccination.J Biomed Sci 27: 66.
-
6.
Ansari SA, Springthorpe VS, Sattar SA, 1991. Survival and vehicular spread of human rotaviruses: Possible relation to seasonality of outbreaks. Rev Infect Dis 13: 448–461.
-
7.
Estes MK, Cohen J, 1989. Rotavirus gene structure and function.Microbiol Rev 53: 410–449.
-
8.
Greenberg HB, Estes MK, 2009. Rotaviruses: From pathogenesis to vaccination. Gastroenterology 136: 1939–1951.
-
9.
World Health Organization, 2007. Rotavirus vaccines. Wkly Epidemiol Rec 82: 285–295.
-
10.
Hung T, Chen GM, Wang CG, 1983. Rotavirus-like agent in adult non-bacterial diarrhea in China. Lancet 5: 1078–1079.
-
11.
Sen A, Kobayashi N, Das S, Krishnan T, Bhattacharya SK, Naik TN, 2001. The evolution of human group B rotaviruses. Lancet 357: 198–199.
-
12.
Kuzuya M, Fujii R, Hamano M, Ohata R, Ogura H, Yamada M, 2001. Seroepidemiology of human group C rotavirus in Japan based on a blocking enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol 8: 161–165.
-
13.
Riepenhoff-Talty M, Morse K, Wang CH, Shapiro C, Roberts J, Welter M, Allen M, Evans MJ, Flanagan TD, 1997. Epidemiology of group C rotavirus infection in Western New York women of childbearing age.J Clin Microbiol 35: 486–488.
-
14.
Hall AJ, Lopman BA, Payne DC, Patel MM, Gastañaduy PA, Vinjé J, Parashar UD, 2013. Norovirus disease in the United States.Emerg Infect Dis 19: 1198–1205.
-
15.
Lopman B, Gastañaduy P, Park GW, Hall AJ, Parashar UD, Vinjé J, 2012. Environmental transmission of norovirus gastroenteritis.Curr Opin Virol 2: 96–102.
-
16.
Iturriza Gómara M, Wong C, Blome S, Desselberger U, Gray J, 2002. Molecular characterization of VP6 genes of human rotavirus isolates: Correlation of genogroups with subgroups and evidence of independent segregation.J Virol 76: 6596–6601.
-
17.
Lin YP, Kao CL, Chang SY, Taniguchi K, Hung PY, Lin HC, Huang LM, Huang HH, Yang JY, Lee CN, 2008. Determination of human rotavirus VP6 genogroups I and II by reverse transcription-PCR.J Clin Microbiol 46: 3330–3337.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 542 | 542 | 200 |
| Full Text Views | 17 | 17 | 7 |
| PDF Downloads | 17 | 17 | 12 |