Author:
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1.
Casel MA, Park SJ, Choi YK, 2021. Severe fever with thrombocytopenia syndrome virus: Emerging novel phlebovirus and their control strategy. Exp Mol Med 53: 713–722.
-
2.
Kim SY, Seo CW, Lee HI, 2023. Severe fever with thrombocytopenia syndrome virus from ticks: A molecular epidemiological study of a patient in the Republic of Korea. Exp Appl Acarol 89: 305–315.
-
3.
Huang X, Li J, Li A, Wang S, Li D, 2021. Epidemiological characteristics of severe fever with thrombocytopenia syndrome from 2010 to 2019 in mainland China. Int J Environ Res Public Health 18: 3092.
-
4.
Kaneko C, Mekata H, Umeki K, Sudaryatma PE, Irie T, Yamada K, Misawa N, Umekita K, Okabayashi T, 2023. Seroprevalence of severe fever with thrombocytopenia syndrome virus in medium-sized wild mammals in Miyazaki, Japan. Ticks Tick Borne Dis 14: 102115.
-
5.
Chen Q, Yang D, Zhang Y, Zhu M, Chen N, Yushan Z, 2022. Transmission and mortality risk assessment of severe fever with thrombocytopenia syndrome in China: Results from 11-years’ study. Infect Dis Poverty 11: 93.
-
6.
Ding S et al., 2014. Age is a critical risk factor for severe fever with thrombocytopenia syndrome. PLoS One 9: e111736.
-
7.
Miyauchi A et al., 2022. Suspected transmission of severe fever with thrombocytopenia syndrome virus from a cat to a veterinarian by a single contact: A case report. Viruses 14: 223.
-
8.
Yamanaka A et al., 2020. Direct transmission of severe fever with thrombocytopenia syndrome virus from domestic cat to veterinary personnel. Emerg Infect Dis 26: 2994–2998.
-
9.
Wu Y-X, Yang X, Leng Y, Li JC, Yuan L, Wang Z, Fan XJ, Yuan C, Liu W, Li H, 2022. Human-to-human transmission of severe fever with thrombocytopenia syndrome virus through potential ocular exposure to infectious blood. Int J Infect Dis 123: 80–83.
-
10.
Tang X et al., 2013. Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood. J Infect Dis 207: 736–739.
-
11.
Bae S et al., 2022. Nosocomial outbreak of severe fever with thrombocytopenia syndrome among healthcare workers in a single hospital in Daegu, Korea. Int J Infect Dis 119: 95–101.
-
12.
Matsuu A et al., 2023. Clinical and pathological findings in fatal cases of severe fever with thrombocytopenia syndrome with high viremia in cats. Top Companion Anim Med 52: 100756.
-
13.
Porter SM, Hartwig AE, Bielefeldt-Ohmann H, Marano JM, Root JJ, Bosco-Lauth AM, 2024. Experimental SARS-CoV-2 infection of elk and mule deer. Emerging Infect Dis 30: 354–357.
-
14.
Liu Y, Wu B, Paessler S, Walker DH, Tesh RB, Yu XJ, 2014. The pathogenesis of severe fever with thrombocytopenia syndrome virus infection in alpha/beta interferon knockout mice: Insights into the pathologic mechanisms of a new viral hemorrhagic fever. J Virol 88: 1781–1786.
-
15.
Matsuu A, Momoi Y, Nishiguchi A, Noguchi K, Yabuki M, Hamakubo E, Take M, Maeda K, 2019. Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan. Vet Microbiol 236: 108346.
-
16.
Reed DS, Bethel LM, Powell DS, Caroline AL, Hartman AL, 2014. Differences in aerosolization of Rift Valley fever virus resulting from choice of inhalation exposure chamber: Implications for animal challenge studies. Pathog Dis 71: 227–233.
-
17.
Chotiwan N et al., 2023. Type I interferon shapes brain distribution and tropism of tick-borne flavivirus. Nat Commun 14: 2007.
-
18.
Sun J, Min YQ, Li Y, Sun X, Deng F, Wang H, Ning YJ, 2022. Animal model of severe fever with thrombocytopenia syndrome virus infection. Front Microbiol 12: 797189.
-
19.
Thornton DJ, Tustin RC, Pienaar BJ, Pienaar WN, Bubb HD, 1975. Cat bite transmission of Yersinia pestis infection to man. J S Afr Vet Assoc 46: 165–169.
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20.
Larson MA, Fey PD, Hinrichs SH, Iwen PC, 2014. Francisella tularensis bacteria associated with feline tularemia in the United States. Emerg Infect Dis 20: 2068–2071.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 19697 | 19697 | 8890 |
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| PDF Downloads | 50 | 50 | 19 |
Exploring Routes of Infection of Severe Fever with Thrombocytopenia Syndrome Virus Using Experimentally Infected Animals
Jeffrey M. Marano
Jeffrey M. Marano
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado
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Angela M. Bosco-Lauth
angela.bosco-lauth@colostate.edu
Angela M. Bosco-Lauth
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado
Search for other papers by Angela M. Bosco-Lauth in
Current site
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Search for other papers by Angela M. Bosco-Lauth in
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ABSTRACT.
Reports from endemic regions in Asia indicate that severe fever with thrombocytopenia syndrome virus (SFTSV), a canonically tick-borne virus, can be directly transmitted from infected humans and animals to naïve hosts. To understand this process, using a feline infection model, we observed that both intramuscular inoculation and oral inoculation resulted in adult cats developing viremia, with cats inoculated intramuscularly shedding virus orally. We also observed a potential organ tropism associated with the route of inoculation. Using an immunodeficient murine model, we further demonstrated that noncanonical routes of inoculation can result in lethal infections. However, we could not replicate the organ tropism seen in cats, possibly because of the immunodeficient nature of the mice. Like cats, mice shed SFSTV orally. These results indicate that SFTSV can exist in a vector-free cycle, highlighting a need for increased surveillance and precautions when handling potentially infected animals.
Author Notes
Financial support: This work was supported in part by the
Current contact information: Jeffrey M. Marano and Angela M. Bosco-Lauth, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, E-mails: jmarano@colostate.edu and angela.bosco-lauth@colostate.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Casel MA, Park SJ, Choi YK, 2021. Severe fever with thrombocytopenia syndrome virus: Emerging novel phlebovirus and their control strategy. Exp Mol Med 53: 713–722.
-
2.
Kim SY, Seo CW, Lee HI, 2023. Severe fever with thrombocytopenia syndrome virus from ticks: A molecular epidemiological study of a patient in the Republic of Korea. Exp Appl Acarol 89: 305–315.
-
3.
Huang X, Li J, Li A, Wang S, Li D, 2021. Epidemiological characteristics of severe fever with thrombocytopenia syndrome from 2010 to 2019 in mainland China. Int J Environ Res Public Health 18: 3092.
-
4.
Kaneko C, Mekata H, Umeki K, Sudaryatma PE, Irie T, Yamada K, Misawa N, Umekita K, Okabayashi T, 2023. Seroprevalence of severe fever with thrombocytopenia syndrome virus in medium-sized wild mammals in Miyazaki, Japan. Ticks Tick Borne Dis 14: 102115.
-
5.
Chen Q, Yang D, Zhang Y, Zhu M, Chen N, Yushan Z, 2022. Transmission and mortality risk assessment of severe fever with thrombocytopenia syndrome in China: Results from 11-years’ study. Infect Dis Poverty 11: 93.
-
6.
Ding S et al., 2014. Age is a critical risk factor for severe fever with thrombocytopenia syndrome. PLoS One 9: e111736.
-
7.
Miyauchi A et al., 2022. Suspected transmission of severe fever with thrombocytopenia syndrome virus from a cat to a veterinarian by a single contact: A case report. Viruses 14: 223.
-
8.
Yamanaka A et al., 2020. Direct transmission of severe fever with thrombocytopenia syndrome virus from domestic cat to veterinary personnel. Emerg Infect Dis 26: 2994–2998.
-
9.
Wu Y-X, Yang X, Leng Y, Li JC, Yuan L, Wang Z, Fan XJ, Yuan C, Liu W, Li H, 2022. Human-to-human transmission of severe fever with thrombocytopenia syndrome virus through potential ocular exposure to infectious blood. Int J Infect Dis 123: 80–83.
-
10.
Tang X et al., 2013. Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood. J Infect Dis 207: 736–739.
-
11.
Bae S et al., 2022. Nosocomial outbreak of severe fever with thrombocytopenia syndrome among healthcare workers in a single hospital in Daegu, Korea. Int J Infect Dis 119: 95–101.
-
12.
Matsuu A et al., 2023. Clinical and pathological findings in fatal cases of severe fever with thrombocytopenia syndrome with high viremia in cats. Top Companion Anim Med 52: 100756.
-
13.
Porter SM, Hartwig AE, Bielefeldt-Ohmann H, Marano JM, Root JJ, Bosco-Lauth AM, 2024. Experimental SARS-CoV-2 infection of elk and mule deer. Emerging Infect Dis 30: 354–357.
-
14.
Liu Y, Wu B, Paessler S, Walker DH, Tesh RB, Yu XJ, 2014. The pathogenesis of severe fever with thrombocytopenia syndrome virus infection in alpha/beta interferon knockout mice: Insights into the pathologic mechanisms of a new viral hemorrhagic fever. J Virol 88: 1781–1786.
-
15.
Matsuu A, Momoi Y, Nishiguchi A, Noguchi K, Yabuki M, Hamakubo E, Take M, Maeda K, 2019. Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan. Vet Microbiol 236: 108346.
-
16.
Reed DS, Bethel LM, Powell DS, Caroline AL, Hartman AL, 2014. Differences in aerosolization of Rift Valley fever virus resulting from choice of inhalation exposure chamber: Implications for animal challenge studies. Pathog Dis 71: 227–233.
-
17.
Chotiwan N et al., 2023. Type I interferon shapes brain distribution and tropism of tick-borne flavivirus. Nat Commun 14: 2007.
-
18.
Sun J, Min YQ, Li Y, Sun X, Deng F, Wang H, Ning YJ, 2022. Animal model of severe fever with thrombocytopenia syndrome virus infection. Front Microbiol 12: 797189.
-
19.
Thornton DJ, Tustin RC, Pienaar BJ, Pienaar WN, Bubb HD, 1975. Cat bite transmission of Yersinia pestis infection to man. J S Afr Vet Assoc 46: 165–169.
-
20.
Larson MA, Fey PD, Hinrichs SH, Iwen PC, 2014. Francisella tularensis bacteria associated with feline tularemia in the United States. Emerg Infect Dis 20: 2068–2071.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 19697 | 19697 | 8890 |
| Full Text Views | 93 | 93 | 26 |
| PDF Downloads | 50 | 50 | 19 |