Author:
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Zotero
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-
1.
Vos T et al., 2020. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet 396: 1204–1222.
-
2.
Ahmed SM, Hall AJ, Robinson AE, Verhoef L, Premkumar P, Parashar UD, Koopmans M, Lopman BA, 2014. Global prevalence of norovirus in cases of gastroenteritis: A systematic review and meta-analysis.Lancet Infect Dis 14: 725–730.
-
3.
Chhabra P et al., 2019. Updated classification of norovirus genogroups and genotypes.J Gen Virol 100: 1393–1406.
-
4.
McAtee CL et al., 2016. Burden of norovirus and rotavirus in children after rotavirus vaccine introduction, Cochabamba, Bolivia.Am J Trop Med Hyg 94: 212–217.
-
5.
da Silva Poló T, Peiró JR, Mendes LCN, Ludwig LF, de Oliveira-Filho EF, Bucardo F, Huynen P, Melin P, Thiry E, Mauroy A, 2016. Human norovirus infection in Latin America.J Clin Virol 78: 111–119.
-
6.
Zambruni M et al., 2016. High prevalence and increased severity of norovirus mixed infections among children 12–24 months of age living in the suburban areas of Lima, Peru.J Pediatric Infect Dis Soc 5: 337–341.
-
7.
Saito M et al., 2014. Multiple norovirus infections in a birth cohort in a Peruvian periurban community.Clin Infect Dis 58: 483–491.
-
8.
Romero C et al., 2017. Incidence of norovirus-associated diarrhea and vomiting disease among children and adults in a community cohort in the Peruvian Amazon basin.Clin Infect Dis 65: 833–839.
-
9.
Mattison CP, Cardemil CV, Hall AJ, 2018. Progress on norovirus vaccine research: Public health considerations and future directions. Expert Rev Vaccines 17: 773–784.
-
10.
Tinoco YO et al., 2017. Burden of influenza in 4 ecologically distinct regions of Peru: Household active surveillance of a community cohort, 2009–2015. Clin Infect Dis 65: 1532–1541.
-
11.
Ministerio De Salud de Peru, 2023. Estadistica Poblacional. Available at: https://www.minsa.gob.pe/reunis/data/poblacion_estimada.asp. Accessed June 21, 2023.
-
12.
Cannon JL, Barclay L, Collins NR, Wikswo ME, Castro CJ, Magaña LC, Gregoricus N, Marine RL, Chhabra P, Vinjé J, 2017. Genetic and epidemiologic trends of norovirus outbreaks in the United States from 2013 to 2016 demonstrated emergence of novel GII.4 recombinant viruses. J Clin Microbiol 55: 2208–2221.
-
13.
Centro Nacional de Epidemologia Prevencion y Control de Enfermedades, 2020. Número de episodios de diarreas agudas, Perú. Available at: https://www.dge.gob.pe/portal/docs/vigilancia/sala/2019/SE52/edas.pdf. Accessed June 19, 2023.
-
14.
O’Ryan M, Riera-Montes M, Lopman B, 2017. Norovirus in Latin America: Systematic review and meta-analysis.Pediatr Infect Dis J 36: 127–134.
-
15.
Becker-Dreps S et al., 2014. Etiology of childhood diarrhea following rotavirus vaccine introduction: A prospective, population-based study in Nicaragua.Pediatr Infect Dis J 33: 1156–1163.
-
16.
Lopman BA et al., 2015. Norovirus infection and disease in an Ecuadorian birth cohort: Association of certain norovirus genotypes with host FUT2 secretor status.J Infect Dis 211: 1813–1821.
-
17.
Grytdal SP, DeBess E, Lee LE, Blythe D, Ryan P, Biggs C, Cameron M, Schmidt M, Parashar UD, Hall AJ, 2016. Incidence of norovirus and other viral pathogens that cause acute gastroenteritis (AGE) among Kaiser Permanente member populations in the United States, 2012–2013. PloS One 11: e0148395.
-
18.
Bernard H, Höhne M, Niendorf S, Altmann D, Stark K, 2014. Epidemiology of norovirus gastroenteritis in Germany 2001–2009: Eight seasons of routine surveillance. Epidemiol Infect 142: 63–74.
-
19.
Kendra JA, Tohma K, Parra GI, 2022. Global and regional circulation trends of norovirus genotypes and recombinants, 1995–2019: A comprehensive review of sequences from public databases.Rev Med Virol 32: e2354.
-
20.
Teunis P, Sukhrie F, Vennema H, Bogerman J, Beersma M, Koopmans M, 2015. Shedding of norovirus in symptomatic and asymptomatic infections. Epidemiol Infect 143: 1710–1717.
-
21.
Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Graham DY, 2008. Norwalk virus shedding after experimental human infection.Emerg Infect Dis 14: 1553–1557.
-
22.
Qi R et al., 2018. Global prevalence of asymptomatic norovirus infection: A meta-analysis. EClinicalMedicine 2–3: 50–58.
-
23.
Gastañaduy PA, Vicuña Y, Salazar F, Broncano N, Gregoricus N, Vinjé J, Chico M, Parashar UD, Cooper PJ, Lopman B, 2015. Transmission of norovirus within households in Quininde, Ecuador.Pediatr Infect Dis J 34: 1031–1033.
-
24.
Phattanawiboon B et al., 2020. Norovirus transmission mediated by asymptomatic family members in households. PLoS One 15: e0236502.
| Past two years | Past Year | Past 30 Days | |
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Incidence of Norovirus-Associated Acute Gastroenteritis across Age Groups in a Peruvian Andean Community
Wesley R. Campbell
Wesley R. Campbell
U.S. Naval Medical Research Unit SOUTH, Lima, Peru;
Division of Infectious Diseases, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland;
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Division of Infectious Diseases, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland;
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Joan Neyra
Joan Neyra
U.S. Naval Medical Research Unit SOUTH, Lima, Peru;
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Laura E. Calderwood
Laura E. Calderwood
National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia;
Cherokee Nation Operational Solutions, Tulsa, Oklahoma;
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Cherokee Nation Operational Solutions, Tulsa, Oklahoma;
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Candice Romero
Candice Romero
Facultad de Medicina Humana, Universidad Nacional de la Amazonía Peruana, Iquitos, Peru;
Vysnova Partners, Inc., Alexandria, Virginia
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Vysnova Partners, Inc., Alexandria, Virginia
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Giselle Soto
Giselle Soto
U.S. Naval Medical Research Unit SOUTH, Lima, Peru;
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Anita K. Kambhampati
Anita K. Kambhampati
National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia;
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Aron J. Hall
Aron J. Hall
National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia;
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Diana Ponce
Diana Ponce
Vysnova Partners, Inc., Alexandria, Virginia
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Patricia Galván
Patricia Galván
U.S. Naval Medical Research Unit SOUTH, Lima, Peru;
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Yeny O. Tinoco
Yeny O. Tinoco
U.S. Naval Medical Research Unit SOUTH, Lima, Peru;
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Jan Vinjé
Jan Vinjé
National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia;
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Umesh D. Parashar
Umesh D. Parashar
National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia;
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Sara A. Mirza
zjk4@cdc.gov
Sara A. Mirza
National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia;
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ABSTRACT.
Norovirus is the leading cause of acute gastroenteritis (AGE) globally. Few longitudinal studies have assessed norovirus-associated AGE incidence across age groups in community settings in Latin America. During April 2015–April 2019, active surveillance for AGE among community members of all ages was conducted through household visits two to three times per week in San Jeronimo, Cusco, Peru. An asymptomatic control household was selected for every fifth AGE case. Stool specimens were collected from AGE cases, asymptomatic household members, and control household members, and they were tested for norovirus using real-time reverse transcriptase polymerase chain reaction. Data on illness characteristics were collected from AGE cases during a 15-day follow-up period. Annual means of 247 households and 1,555 participants were enrolled during each April–March surveillance year, accounting for 4,176 person-years (PY) of observation. Of 1,099 AGE events reported, 1,014 stool specimens were tested, and 186 (18%) were norovirus positive. Norovirus AGE incidence was 4.4/100 PY (95% CI: 3.9–5.1); incidence was highest among those younger than 2 years old (60.9/100 PY; 95% CI: 46.8–79.4). Among 672 stool specimens from asymptomatic controls, 56 (8%) tested positive for norovirus. Odds of norovirus detection were significantly higher among cases compared with controls (odds ratio: 2.2; 95% CI: 1.6–3.1). Age-stratified norovirus incidence in this periurban community aligns with previously published estimates and was highest among those younger than 2 years old. Establishing baseline norovirus incidence in specific communities is crucial to identify target populations and assess effectiveness of future interventions, such as vaccines.
Author Notes
Financial support: This work was supported by an Interagency Agreement
Disclosures: The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defense, or the U.S. Government. The study protocol was approved by the U.S. Naval Medical Research Unit SOUTH Institutional Review Board (Protocol NAMRU6.2012.0013) in compliance with all applicable federal regulations governing the protection of human subjects. Some authors are military service members and employees of the U.S. Government. This work was prepared as part of their official duties. Title 17 U.S.C. §105 provides that “Copyright protection under this title is not available for any work of the United States Government.” Title 17 U.S.C. §101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person’s official duties.
Current contact information: Wesley R. Campbell, Division of Infectious Diseases, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, E-mail: wesley.r.campbell.mil@health.mil. Joan Neyra, Giselle Soto, Patricia Galván, and Yeny O. Tinoco, U.S. Naval Medical Research Unit SOUTH, Lima, Peru, E-mails: joan.m.neyra2.ln@health.mil, giselle.m.soto.ln@health.mil, patricia.galvan2.ln@health.mil, and yeny.o.tinoco.ln@health.mil. Laura E. Calderwood, Cherokee Nation Operational Solutions, Tulsa, OK, and National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, E-mail: ofc1@cdc.gov. Candice Romero, Facultad de Medicina Humana, Universidad Nacional de la Amazonía Peruana, Iquitos, Peru, and Vysnova Partners, Inc., Alexandria, VA, E-mail: candice.romero.ctr@health.mil. Anita K. Kambhampati, Aron J. Hall, Jan Vinjé, Umesh D. Parashar, and Sara A. Mirza, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, E-mails: wyc4@cdc.gov, esg3@cdc.gov, ahx8@cdc.gov, uap2@cdc.gov, and zjk4@cdc.gov. Diana Ponce, Vysnova Partners, Inc., Alexandria, VA, E-mail: diana.m.ponce.ctr@health.mil.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Vos T et al., 2020. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet 396: 1204–1222.
-
2.
Ahmed SM, Hall AJ, Robinson AE, Verhoef L, Premkumar P, Parashar UD, Koopmans M, Lopman BA, 2014. Global prevalence of norovirus in cases of gastroenteritis: A systematic review and meta-analysis.Lancet Infect Dis 14: 725–730.
-
3.
Chhabra P et al., 2019. Updated classification of norovirus genogroups and genotypes.J Gen Virol 100: 1393–1406.
-
4.
McAtee CL et al., 2016. Burden of norovirus and rotavirus in children after rotavirus vaccine introduction, Cochabamba, Bolivia.Am J Trop Med Hyg 94: 212–217.
-
5.
da Silva Poló T, Peiró JR, Mendes LCN, Ludwig LF, de Oliveira-Filho EF, Bucardo F, Huynen P, Melin P, Thiry E, Mauroy A, 2016. Human norovirus infection in Latin America.J Clin Virol 78: 111–119.
-
6.
Zambruni M et al., 2016. High prevalence and increased severity of norovirus mixed infections among children 12–24 months of age living in the suburban areas of Lima, Peru.J Pediatric Infect Dis Soc 5: 337–341.
-
7.
Saito M et al., 2014. Multiple norovirus infections in a birth cohort in a Peruvian periurban community.Clin Infect Dis 58: 483–491.
-
8.
Romero C et al., 2017. Incidence of norovirus-associated diarrhea and vomiting disease among children and adults in a community cohort in the Peruvian Amazon basin.Clin Infect Dis 65: 833–839.
-
9.
Mattison CP, Cardemil CV, Hall AJ, 2018. Progress on norovirus vaccine research: Public health considerations and future directions. Expert Rev Vaccines 17: 773–784.
-
10.
Tinoco YO et al., 2017. Burden of influenza in 4 ecologically distinct regions of Peru: Household active surveillance of a community cohort, 2009–2015. Clin Infect Dis 65: 1532–1541.
-
11.
Ministerio De Salud de Peru, 2023. Estadistica Poblacional. Available at: https://www.minsa.gob.pe/reunis/data/poblacion_estimada.asp. Accessed June 21, 2023.
-
12.
Cannon JL, Barclay L, Collins NR, Wikswo ME, Castro CJ, Magaña LC, Gregoricus N, Marine RL, Chhabra P, Vinjé J, 2017. Genetic and epidemiologic trends of norovirus outbreaks in the United States from 2013 to 2016 demonstrated emergence of novel GII.4 recombinant viruses. J Clin Microbiol 55: 2208–2221.
-
13.
Centro Nacional de Epidemologia Prevencion y Control de Enfermedades, 2020. Número de episodios de diarreas agudas, Perú. Available at: https://www.dge.gob.pe/portal/docs/vigilancia/sala/2019/SE52/edas.pdf. Accessed June 19, 2023.
-
14.
O’Ryan M, Riera-Montes M, Lopman B, 2017. Norovirus in Latin America: Systematic review and meta-analysis.Pediatr Infect Dis J 36: 127–134.
-
15.
Becker-Dreps S et al., 2014. Etiology of childhood diarrhea following rotavirus vaccine introduction: A prospective, population-based study in Nicaragua.Pediatr Infect Dis J 33: 1156–1163.
-
16.
Lopman BA et al., 2015. Norovirus infection and disease in an Ecuadorian birth cohort: Association of certain norovirus genotypes with host FUT2 secretor status.J Infect Dis 211: 1813–1821.
-
17.
Grytdal SP, DeBess E, Lee LE, Blythe D, Ryan P, Biggs C, Cameron M, Schmidt M, Parashar UD, Hall AJ, 2016. Incidence of norovirus and other viral pathogens that cause acute gastroenteritis (AGE) among Kaiser Permanente member populations in the United States, 2012–2013. PloS One 11: e0148395.
-
18.
Bernard H, Höhne M, Niendorf S, Altmann D, Stark K, 2014. Epidemiology of norovirus gastroenteritis in Germany 2001–2009: Eight seasons of routine surveillance. Epidemiol Infect 142: 63–74.
-
19.
Kendra JA, Tohma K, Parra GI, 2022. Global and regional circulation trends of norovirus genotypes and recombinants, 1995–2019: A comprehensive review of sequences from public databases.Rev Med Virol 32: e2354.
-
20.
Teunis P, Sukhrie F, Vennema H, Bogerman J, Beersma M, Koopmans M, 2015. Shedding of norovirus in symptomatic and asymptomatic infections. Epidemiol Infect 143: 1710–1717.
-
21.
Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Graham DY, 2008. Norwalk virus shedding after experimental human infection.Emerg Infect Dis 14: 1553–1557.
-
22.
Qi R et al., 2018. Global prevalence of asymptomatic norovirus infection: A meta-analysis. EClinicalMedicine 2–3: 50–58.
-
23.
Gastañaduy PA, Vicuña Y, Salazar F, Broncano N, Gregoricus N, Vinjé J, Chico M, Parashar UD, Cooper PJ, Lopman B, 2015. Transmission of norovirus within households in Quininde, Ecuador.Pediatr Infect Dis J 34: 1031–1033.
-
24.
Phattanawiboon B et al., 2020. Norovirus transmission mediated by asymptomatic family members in households. PLoS One 15: e0236502.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1046 | 1046 | 110 |
| Full Text Views | 32 | 32 | 14 |
| PDF Downloads | 36 | 36 | 16 |