ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Montufar C , Hidalgo J , Gei AF (eds.), 2021. Obstetric Catastrophes: A Clinical Guide. Cham, Switzerland: Springer Nature.
-
2.
Adem PV , 2019. Emerging and re-emerging rickettsial infections. Semin Diagn Pathol 36: 146–151.
-
3.
Álvarez-López DI , Ochoa-Mora E , Nichols Heitman K , Binder AM , Álvarez-Hernández G , Armstrong PA , 2021. Epidemiology and clinical features of Rocky Mountain spotted fever from enhanced surveillance, Sonora, Mexico: 2015–2018. Am J Trop Med Hyg 104: 190–197.
-
4.
Government of Mexico, Secretary of Health , 2022. Boletín Epidemiológico: Sistema Nacional de Vigilancia Epidemiológica: Sistema Unico de Información. Available at: https://www.gob.mx/salud/acciones-y-programas/direccion-general-de-epidemiologia-boletin-epidemiologico. Accessed July 19, 2022.
-
5.
Sahni A , Fang R , Sahni SK , Walker DH , 2019. Pathogenesis of rickettsial diseases: pathogenic and immune mechanisms of an endotheliotropic infection. Annu Rev Pathol 14: 127–152.
-
6.
Husin NA , AbuBakar S , Khoo JJ , 2021. Current tools for the diagnosis and detection of spotted fever group Rickettsia. Acta Trop 218: 105887.
-
7.
Blanton LS , 2019. The rickettsioses. Infect Dis Clin North Am 33: 213–229.
-
8.
Delgado-De la Mora J , Licona-Enríquez JD , Álvarez-López DI , Aguilar-León DE , Álvarez-Hernández G , 2021. Características clínicas de los pacientes con fiebre manchada de las Montañas Rocosas, infección por dengue y chikungunya. Gac Med Mex 157: 61–66.
-
9.
Jay R , Armstrong PA , 2020. Clinical characteristics of Rocky Mountain spotted fever in the United States: a literature review. J Vector Borne Dis 57: 114–120.
-
10.
Licona-Enriquez JD , Delgado-de la Mora J , Hernández GÁ , Ramirez-Rodriguez CA , Candia-Plata MdelC , Paddock CD , 2017. Rocky Mountain spotted fever and pregnancy: four cases from Sonora, Mexico. Am J Trop Med Hyg 97: 795–798.
-
11.
Stallings SP , 2001. Rocky Mountain spotted fever and pregnancy: a case report and review of the literature. Obstet Gynecol Surv 56: 37–42.
-
12.
Bentov Y , Sheiner E , Kenigsberg S , Mazor M , 2003. Mediterranean spotted fever during pregnancy: case presentation and literature review. Eur J Obstet Gynecol Reprod Biol 107: 214–216.
-
13.
Curto P , Santa C , Cortes L , Manadas B , Simões I , 2021. Spotted fever group Rickettsia trigger species-specific alterations in macrophage proteome signatures with different impacts in host innate inflammatory responses. Microbiol Spectr 9: e0081421.
-
14.
Ratnayake RMCJ , Wanasinghe WMMPB , Dissanayake P , Kularatne SAM , Pinto MVG , Jayasinghearachchi TMK , Rajapakse RPVJ , 2021. Spotted fever rickettsial infection in pregnancy causing acute hepatitis, fatal postpartum hemorrhage and possible vertical transmission. Asian J Infect Dis 7: 1–5.
-
15.
Biggs HM et al., 2016. Diagnosis and management of tick-borne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis – United States. MMWR Recomm Rep 65: 1–44.
-
16.
Paddock CD et al., 1999. Hidden mortality attributable to Rocky Mountain spotted fever: immunohistochemical detection of fatal, serologically unconfirmed disease. J Infect Dis 179: 1469–1476.
-
17.
Paddock CD , 2013. Perspectives on the laboratory diagnosis of rickettsial diseases in the 21st century. Acta Med Costarric 55 (Suppl 1 ):13–24.
-
18.
Dumler JS , 2012. Clinical disease: Current treatment and new challenges. GH Palmer, AF Azad, eds. Intracellular Pathogens II: Rickettsiales. Washington, DC: ASM Press, 1–39.
-
19.
Walker DH , Myers CTE , Blanton LS , Bloch KC , Fowler VG Jr. , Gaines DN , Paddock CD , Yaglom HD , 2022. Rickettsiosis subcommittee report to the tick-borne disease working group. Ticks Tick Borne Dis 13: 101855.
-
20.
Cooper WO , Hernandez-Diaz S , Arbogast PG , Dudley JA , Dyer SM , Gideon PS , Hall KS , Kaltenbach LA , Ray WA , 2009. Antibiotics potentially used in response to bioterrorism and the risk of major congenital malformations. Paediatr Perinat Epidemiol 23: 18–28.
-
21.
Cross R , Ling C , Day NP , McGready R , Paris DH , 2016. Revisiting doxycycline in pregnancy and early childhood: time to rebuild its reputation? Expert Opin Drug Saf 15: 367–382.
-
22.
Czeizel AE , Rockenbauer M , 1997. Teratogenic study of doxycycline. Obstet Gynecol 89: 524–528.
-
23.
U.S. Food and Drug Administration 2022. Bioterrorism and Drug Preparedness. Available at: https://www.fda.gov/drugs/emergency-preparedness-drugs/bioterrorism-and-drug-preparedness. Accessed January 12, 2022.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1889 | 1889 | 59 |
| Full Text Views | 52 | 52 | 2 |
| PDF Downloads | 73 | 73 | 5 |
Case Report: Fatal Rickettsiosis in Pregnancy
Eduardo Ponce Nájera
Eduardo Ponce Nájera
Hospital Regional Materno Infantil del Estado de Nuevo León, Nuevo León, Mexico;
Escuela de Medicina y Ciencias de la Salud Tecnológico de Monterrey, Nuevo León, Mexico;
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Escuela de Medicina y Ciencias de la Salud Tecnológico de Monterrey, Nuevo León, Mexico;
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Valeria Lozano Lazcano
Valeria Lozano Lazcano
Hospital Regional Materno Infantil del Estado de Nuevo León, Nuevo León, Mexico;
Escuela de Medicina y Ciencias de la Salud Tecnológico de Monterrey, Nuevo León, Mexico;
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Escuela de Medicina y Ciencias de la Salud Tecnológico de Monterrey, Nuevo León, Mexico;
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César Ploneda González
César Ploneda González
Hospital Metropolitano “Dr. Bernardo Sepúlveda’’ del Estado de Nuevo León, Nuevo León, Mexico
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Marcela Montoya Hinojosa
Marcela Montoya Hinojosa
Hospital Regional Materno Infantil del Estado de Nuevo León, Nuevo León, Mexico;
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Diego González Oropeza
Diego González Oropeza
Hospital Regional Materno Infantil del Estado de Nuevo León, Nuevo León, Mexico;
Escuela de Medicina y Ciencias de la Salud Tecnológico de Monterrey, Nuevo León, Mexico;
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Escuela de Medicina y Ciencias de la Salud Tecnológico de Monterrey, Nuevo León, Mexico;
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ABSTRACT.
Rocky Mountain spotted fever (RMSF) is a tick-borne infection caused by Rickettsia rickettsii. We present a series of two cases of pregnant patients who showed up at the emergency room of a hospital in Nuevo León, Mexico. Both patients lived in environments where R. rickettsii is endemic and they presented with several days of symptoms, including fever. Both patients developed a rash and had stillbirths during their hospital stay. Treatment with doxycycline was delayed, with fatal results in both patients. Diagnosis of RMSF was confirmed via polymerase chain reaction assay postmortem. The need to link epidemiological clues with clinical data is critical in the diagnosis and early treatment of RMSF to prevent maternal deaths.
Author Notes
Authors’ addresses: Eduardo Ponce Nájera, Valeria Lozano Lazcano, Marcela Montoya Hinojosa, and Diego González Oropeza, Hospital Regional Materno Infantil del Estado de Nuevo León, Nuevo León, Mexico, E-mails: eponcenajera@gmail.com, vrlozanol95@gmail.com, marcemontoya.1499@gmail.com, and diego.oropeza@saludnl.gob.mx. César Ploneda González, Hospital Metropolitano “Dr. Bernardo Sepúlveda’’ del Estado de Nuevo León, Nuevo León, Mexico, E-mail: cesar.ploneda@saludnl.gob.mx.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Montufar C , Hidalgo J , Gei AF (eds.), 2021. Obstetric Catastrophes: A Clinical Guide. Cham, Switzerland: Springer Nature.
-
2.
Adem PV , 2019. Emerging and re-emerging rickettsial infections. Semin Diagn Pathol 36: 146–151.
-
3.
Álvarez-López DI , Ochoa-Mora E , Nichols Heitman K , Binder AM , Álvarez-Hernández G , Armstrong PA , 2021. Epidemiology and clinical features of Rocky Mountain spotted fever from enhanced surveillance, Sonora, Mexico: 2015–2018. Am J Trop Med Hyg 104: 190–197.
-
4.
Government of Mexico, Secretary of Health , 2022. Boletín Epidemiológico: Sistema Nacional de Vigilancia Epidemiológica: Sistema Unico de Información. Available at: https://www.gob.mx/salud/acciones-y-programas/direccion-general-de-epidemiologia-boletin-epidemiologico. Accessed July 19, 2022.
-
5.
Sahni A , Fang R , Sahni SK , Walker DH , 2019. Pathogenesis of rickettsial diseases: pathogenic and immune mechanisms of an endotheliotropic infection. Annu Rev Pathol 14: 127–152.
-
6.
Husin NA , AbuBakar S , Khoo JJ , 2021. Current tools for the diagnosis and detection of spotted fever group Rickettsia. Acta Trop 218: 105887.
-
7.
Blanton LS , 2019. The rickettsioses. Infect Dis Clin North Am 33: 213–229.
-
8.
Delgado-De la Mora J , Licona-Enríquez JD , Álvarez-López DI , Aguilar-León DE , Álvarez-Hernández G , 2021. Características clínicas de los pacientes con fiebre manchada de las Montañas Rocosas, infección por dengue y chikungunya. Gac Med Mex 157: 61–66.
-
9.
Jay R , Armstrong PA , 2020. Clinical characteristics of Rocky Mountain spotted fever in the United States: a literature review. J Vector Borne Dis 57: 114–120.
-
10.
Licona-Enriquez JD , Delgado-de la Mora J , Hernández GÁ , Ramirez-Rodriguez CA , Candia-Plata MdelC , Paddock CD , 2017. Rocky Mountain spotted fever and pregnancy: four cases from Sonora, Mexico. Am J Trop Med Hyg 97: 795–798.
-
11.
Stallings SP , 2001. Rocky Mountain spotted fever and pregnancy: a case report and review of the literature. Obstet Gynecol Surv 56: 37–42.
-
12.
Bentov Y , Sheiner E , Kenigsberg S , Mazor M , 2003. Mediterranean spotted fever during pregnancy: case presentation and literature review. Eur J Obstet Gynecol Reprod Biol 107: 214–216.
-
13.
Curto P , Santa C , Cortes L , Manadas B , Simões I , 2021. Spotted fever group Rickettsia trigger species-specific alterations in macrophage proteome signatures with different impacts in host innate inflammatory responses. Microbiol Spectr 9: e0081421.
-
14.
Ratnayake RMCJ , Wanasinghe WMMPB , Dissanayake P , Kularatne SAM , Pinto MVG , Jayasinghearachchi TMK , Rajapakse RPVJ , 2021. Spotted fever rickettsial infection in pregnancy causing acute hepatitis, fatal postpartum hemorrhage and possible vertical transmission. Asian J Infect Dis 7: 1–5.
-
15.
Biggs HM et al., 2016. Diagnosis and management of tick-borne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis – United States. MMWR Recomm Rep 65: 1–44.
-
16.
Paddock CD et al., 1999. Hidden mortality attributable to Rocky Mountain spotted fever: immunohistochemical detection of fatal, serologically unconfirmed disease. J Infect Dis 179: 1469–1476.
-
17.
Paddock CD , 2013. Perspectives on the laboratory diagnosis of rickettsial diseases in the 21st century. Acta Med Costarric 55 (Suppl 1 ):13–24.
-
18.
Dumler JS , 2012. Clinical disease: Current treatment and new challenges. GH Palmer, AF Azad, eds. Intracellular Pathogens II: Rickettsiales. Washington, DC: ASM Press, 1–39.
-
19.
Walker DH , Myers CTE , Blanton LS , Bloch KC , Fowler VG Jr. , Gaines DN , Paddock CD , Yaglom HD , 2022. Rickettsiosis subcommittee report to the tick-borne disease working group. Ticks Tick Borne Dis 13: 101855.
-
20.
Cooper WO , Hernandez-Diaz S , Arbogast PG , Dudley JA , Dyer SM , Gideon PS , Hall KS , Kaltenbach LA , Ray WA , 2009. Antibiotics potentially used in response to bioterrorism and the risk of major congenital malformations. Paediatr Perinat Epidemiol 23: 18–28.
-
21.
Cross R , Ling C , Day NP , McGready R , Paris DH , 2016. Revisiting doxycycline in pregnancy and early childhood: time to rebuild its reputation? Expert Opin Drug Saf 15: 367–382.
-
22.
Czeizel AE , Rockenbauer M , 1997. Teratogenic study of doxycycline. Obstet Gynecol 89: 524–528.
-
23.
U.S. Food and Drug Administration 2022. Bioterrorism and Drug Preparedness. Available at: https://www.fda.gov/drugs/emergency-preparedness-drugs/bioterrorism-and-drug-preparedness. Accessed January 12, 2022.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1889 | 1889 | 59 |
| Full Text Views | 52 | 52 | 2 |
| PDF Downloads | 73 | 73 | 5 |