ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Tindall SC , 1990. Clinical Methods: The History, Physical, and Laboratory Examinations. Boston, MA: Butterworths.
-
2.
Basak D , Chatterjee S , Attergrim J , Sharma MR , Soni KD , Verma S , GerdinWärnberg M , Roy N , 2023. Glasgow coma scale compared to other trauma scores in discriminating in-hospital mortality of traumatic brain injury patients admitted to urban Indian hospitals: a multicentre prospective cohort study. Injury 54: 93–99.
-
3.
Morgulis A , Coulouris G , Raytselis Y , Madden TL , Agarwala R , Schaffer AA , 2008. Database indexing for production MegaBLAST searches. Bioinformatics 24: 1757–1764.
-
4.
Zhang Z , Schwartz S , Wagner L , Miller W , 2000. A greedy algorithm for aligning DNA sequences. J Comput Biol 7: 203–214.
-
5.
Garzoni C , Markham L , Bijlenga P , Garbino J , 2008. Cladophialophora bantiana: a rare cause of fungal brain abscess. Clinical aspects and new therapeutic options. Med Mycol 46: 481–486.
-
6.
Brandt ME , Warnock DW , 2003. Epidemiology, clinical manifestations, and therapy of infections caused by dematiaceous fungi. J Chemother 15 (Suppl 2 ):36–47.
-
7.
Revankar SG , Sutton DA , Rinaldi MG , 2004. Primary central nervous system phaeohyphomycosis: a review of 101 cases. Clin Infect Dis 38: 206–216.
-
8.
Revankar SG , Sutton DA , 2010. Melanized fungi in human disease. Clin Microbiol Rev 23: 884–928.
-
9.
Guarro JHS , Jorgensen JH , Guido Funke KCC , Pfaller MA , Landry ML , Richter SS & Warnock DW Manual of Clinical Microbiology, 11th ed. Washington, DC: ASM, 2153–2172.
-
10.
De Hoog GS , Attili-Angelis D , Vicente VA , Van Den Ende AH , Queiroz-Telles F , 2004. Molecular ecology and pathogenic potential of Fonsecaea species. Med Mycol 42: 405–416.
-
11.
Nobrega JP , Rosemberg S , Adami AM , Heins-Vaccari EM , Lacaz Cda S , de Brito T , 2003. Fonsecaea pedrosoi cerebral phaeohyphomycosis (“chromoblastomycosis”): first human culture-proven case reported in Brazil. Rev Inst Med Trop São Paulo 45: 217–220.
-
12.
Surash S , Tyagi A , De Hoog GS , Zeng JS , Barton RC , Hobson RP , 2005. Cerebral phaeohyphomycosis caused by Fonsecaea monophora. Med Mycol 43: 465–472.
-
13.
Takei H , Goodman JC , Powell SZ , 2007. Cerebral phaeohyphomycosis caused by ladophialophora bantiana and Fonsecaea monophora: report of three cases. Clin Neuropathol 26: 21–27.
-
14.
Koo S , Klompas M , Marty FM , 2010. Fonsecaea monophora cerebral phaeohyphomycosis: case report of successful surgical excision and voriconazole treatment and review. Med Mycol 48: 769–774.
-
15.
Doymaz MZ , Seyithanoglu MF , Hakyemez I , Gultepe BS , Cevik S , Aslan T , 2015. A case of cerebral phaeohyphomycosis caused by Fonsecaea monophora, a neurotropic dematiaceous fungus, and a review of the literature. Mycoses 58: 187–192.
-
16.
Bagla P , Loeffelholz M , Blanton LS , 2016. Cerebral phaeohyphomycosis by Fonsecaea monophora: report in a patient with AIDS and a ring enhancing lesion. Med Mycol Case Rep 12: 4–7.
-
17.
Varghese P , Jalal MJA , Ahmad S , Khan Z , Johny M , Mahadevan P , Joseph L , Chandy R , Paul S , 2016. Cerebral phaeohyphomycosis caused by Fonsecaea monophora: first report from India. Int J Surg Med 2: 44–49.
-
18.
Stokes W , Fuller J , Meier-Stephenson V , Remington R , Meatherall BL , 2017. Case report of cerebral phaeohyphomycosis caused by Fonsecaea monophora. JAMMI 2: 86–92.
-
19.
Dobias R et al., 2019. Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature. Folia Microbiol (Praha) 64: 383–388.
-
20.
Helbig S , Thuermer A , Dengl M , Krukowski P , de With K , 2018. Cerebral abscess by Fonsecaea monophora–the first case reported in Germany. Open Forum Infect Dis 5: ofy129.
-
21.
Lutsar I , Roffey S , Troke P , 2003. Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients. Clin Infect Dis 37: 728–732.
-
22.
Chen K , Zhang X , Ke X , Du G , Yang K , Zhai S , 2018. Individualized medication of voriconazole: a practice guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society. Ther Drug Monit 40: 663–674.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1451 | 1451 | 49 |
| Full Text Views | 59 | 59 | 0 |
| PDF Downloads | 79 | 79 | 0 |
Case Report: Successful Treatment of Cerebral Phaeohyphomycosis with Voriconazole: A Case Report and Literature Review
Hao Bai
Hao Bai
Department of Pharmacy, Chongqing University Cancer Hospital, Chongqing, China;
Search for other papers by Hao Bai in
Current site
Google Scholar
PubMed
Search for other papers by Hao Bai in
Current site
Google Scholar
PubMed
Chao Li
Chao Li
Department of Pharmacy, Chongqing University Cancer Hospital, Chongqing, China;
Search for other papers by Chao Li in
Current site
Google Scholar
PubMed
Search for other papers by Chao Li in
Current site
Google Scholar
PubMed
Xiangyu Lai
Xiangyu Lai
Department of Pharmacy, Chongqing University Cancer Hospital, Chongqing, China;
Search for other papers by Xiangyu Lai in
Current site
Google Scholar
PubMed
Search for other papers by Xiangyu Lai in
Current site
Google Scholar
PubMed
Xiaogang Hu
Xiaogang Hu
Department of Pharmacy, Chongqing University Cancer Hospital, Chongqing, China;
Search for other papers by Xiaogang Hu in
Current site
Google Scholar
PubMed
Search for other papers by Xiaogang Hu in
Current site
Google Scholar
PubMed
Lixian Li
Lixian Li
Department of Pharmacy, Chongqing University Cancer Hospital, Chongqing, China;
Search for other papers by Lixian Li in
Current site
Google Scholar
PubMed
Search for other papers by Lixian Li in
Current site
Google Scholar
PubMed
Wanyi Chen
Wanyi Chen
Department of Pharmacy, Chongqing University Cancer Hospital, Chongqing, China;
College of Bioengineering, Chongqing University, Chongqing, China
Search for other papers by Wanyi Chen in
Current site
Google Scholar
PubMed
College of Bioengineering, Chongqing University, Chongqing, China
Search for other papers by Wanyi Chen in
Current site
Google Scholar
PubMed
ABSTRACT.
Fonsecaea monophora is a species of Fonsecaea that belongs to Chaetothyriales. It is usually isolated from tropical and subtropical regions, causing reactive inflammation, skin abscesses, and pain. Cerebral infection caused by F. monophora is rare but often fatal. Diagnosing this disease at an early stage is difficult, and appropriate antifungal therapy is often delayed as a result. We report the case of a 53-year-old woman with type 2 diabetes who presented with a headache 2 months ago and progressive right-sided weakness of 1 month’s duration. Magnetic resonance imaging revealed a space-occupying lesion in the left frontal lobe and corpus callosum. The cystic mass was removed by surgical intervention, and the identification of the sample based on sequencing of the internal transcribed spaced region in BLAST-N search showed that the sequences producing most significant alignments were F. monophora or similar (query cover 99%, E value 0.0, per ident 99.84). The patient was treated with a 3-month course of twice daily voriconazole, leading to complete recovery.
- Supplemental Materials (PDF 140.23 KB)
Author Notes
Financial support: This work was supported by the
Disclosure: Our institution does not require ethical approval for reporting individual cases or case series.
Authors’ addresses: Hao Bai, Chao Li, Xiangyu Lai, Xiaogang Hu, and Lixian Li, Department of Pharmacy, Chongqing University Cancer Hospital, Chongqing, China, E-mails: 474027594@qq.com, lichaolucy@sina.com, 510327039@qq.com, hxgcq1987@126.com, and lilixian2010@yahoo.com. Wanyi Chen, Department of Pharmacy, Chongqing University Cancer Hospital, Chongqing, China, and College of Bioengineering, Chongqing University, Chongqing, China, E-mail: 32003371@qq.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Tindall SC , 1990. Clinical Methods: The History, Physical, and Laboratory Examinations. Boston, MA: Butterworths.
-
2.
Basak D , Chatterjee S , Attergrim J , Sharma MR , Soni KD , Verma S , GerdinWärnberg M , Roy N , 2023. Glasgow coma scale compared to other trauma scores in discriminating in-hospital mortality of traumatic brain injury patients admitted to urban Indian hospitals: a multicentre prospective cohort study. Injury 54: 93–99.
-
3.
Morgulis A , Coulouris G , Raytselis Y , Madden TL , Agarwala R , Schaffer AA , 2008. Database indexing for production MegaBLAST searches. Bioinformatics 24: 1757–1764.
-
4.
Zhang Z , Schwartz S , Wagner L , Miller W , 2000. A greedy algorithm for aligning DNA sequences. J Comput Biol 7: 203–214.
-
5.
Garzoni C , Markham L , Bijlenga P , Garbino J , 2008. Cladophialophora bantiana: a rare cause of fungal brain abscess. Clinical aspects and new therapeutic options. Med Mycol 46: 481–486.
-
6.
Brandt ME , Warnock DW , 2003. Epidemiology, clinical manifestations, and therapy of infections caused by dematiaceous fungi. J Chemother 15 (Suppl 2 ):36–47.
-
7.
Revankar SG , Sutton DA , Rinaldi MG , 2004. Primary central nervous system phaeohyphomycosis: a review of 101 cases. Clin Infect Dis 38: 206–216.
-
8.
Revankar SG , Sutton DA , 2010. Melanized fungi in human disease. Clin Microbiol Rev 23: 884–928.
-
9.
Guarro JHS , Jorgensen JH , Guido Funke KCC , Pfaller MA , Landry ML , Richter SS & Warnock DW Manual of Clinical Microbiology, 11th ed. Washington, DC: ASM, 2153–2172.
-
10.
De Hoog GS , Attili-Angelis D , Vicente VA , Van Den Ende AH , Queiroz-Telles F , 2004. Molecular ecology and pathogenic potential of Fonsecaea species. Med Mycol 42: 405–416.
-
11.
Nobrega JP , Rosemberg S , Adami AM , Heins-Vaccari EM , Lacaz Cda S , de Brito T , 2003. Fonsecaea pedrosoi cerebral phaeohyphomycosis (“chromoblastomycosis”): first human culture-proven case reported in Brazil. Rev Inst Med Trop São Paulo 45: 217–220.
-
12.
Surash S , Tyagi A , De Hoog GS , Zeng JS , Barton RC , Hobson RP , 2005. Cerebral phaeohyphomycosis caused by Fonsecaea monophora. Med Mycol 43: 465–472.
-
13.
Takei H , Goodman JC , Powell SZ , 2007. Cerebral phaeohyphomycosis caused by ladophialophora bantiana and Fonsecaea monophora: report of three cases. Clin Neuropathol 26: 21–27.
-
14.
Koo S , Klompas M , Marty FM , 2010. Fonsecaea monophora cerebral phaeohyphomycosis: case report of successful surgical excision and voriconazole treatment and review. Med Mycol 48: 769–774.
-
15.
Doymaz MZ , Seyithanoglu MF , Hakyemez I , Gultepe BS , Cevik S , Aslan T , 2015. A case of cerebral phaeohyphomycosis caused by Fonsecaea monophora, a neurotropic dematiaceous fungus, and a review of the literature. Mycoses 58: 187–192.
-
16.
Bagla P , Loeffelholz M , Blanton LS , 2016. Cerebral phaeohyphomycosis by Fonsecaea monophora: report in a patient with AIDS and a ring enhancing lesion. Med Mycol Case Rep 12: 4–7.
-
17.
Varghese P , Jalal MJA , Ahmad S , Khan Z , Johny M , Mahadevan P , Joseph L , Chandy R , Paul S , 2016. Cerebral phaeohyphomycosis caused by Fonsecaea monophora: first report from India. Int J Surg Med 2: 44–49.
-
18.
Stokes W , Fuller J , Meier-Stephenson V , Remington R , Meatherall BL , 2017. Case report of cerebral phaeohyphomycosis caused by Fonsecaea monophora. JAMMI 2: 86–92.
-
19.
Dobias R et al., 2019. Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature. Folia Microbiol (Praha) 64: 383–388.
-
20.
Helbig S , Thuermer A , Dengl M , Krukowski P , de With K , 2018. Cerebral abscess by Fonsecaea monophora–the first case reported in Germany. Open Forum Infect Dis 5: ofy129.
-
21.
Lutsar I , Roffey S , Troke P , 2003. Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients. Clin Infect Dis 37: 728–732.
-
22.
Chen K , Zhang X , Ke X , Du G , Yang K , Zhai S , 2018. Individualized medication of voriconazole: a practice guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society. Ther Drug Monit 40: 663–674.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1451 | 1451 | 49 |
| Full Text Views | 59 | 59 | 0 |
| PDF Downloads | 79 | 79 | 0 |