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Antioxidants do not Prevent the In Vitro Induction of Plasmodium Falciparum Crisis Forms by Human Malaria-Immune, TB or Rabbit TNF Serum
Timothy G. Geary
Timothy G. Geary
Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48824-1101
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Michael T. Boland
Michael T. Boland
Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48824-1101
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James B. Jensen
James B. Jensen
Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48824-1101
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Cultured Plasmodium falciparum was retarded in intraerythrocytic development by serum from malaria-immune adults, by human TB serum, and by rabbit tumor necrosis serum. Neither the potency nor efficacy of any of these sera was altered by a variety of antioxidants or oxygen-free radial scavengers, including ascorbate, α-tocopherol, BHT, cystine or cyteine, glutathione, histidine, phenylalanine, tryptophan, tyrosine, superoxide dismutase, catalase (or combination of the two enzymes), or by reducing the ambient O2 tension to 1%. It is thus unlikely that the antiparasitic activity of these inhibitory sera can be attributed to oxidative mechanisms.
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