1921
image of Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

, the etiological agent of Chagas diseases, invades the cardiac tissue causing acute myocarditis and heart electrical disturbances. In invasion, the parasite induces [Ca] transients in the host cells, an essential phenomenon for invasion. To date, knowledge on the mechanism that elicits transients of [Ca] during the infection of cardiac myocytes has not been fully characterized. Pannexin1 (Panx1) channel are poorly selective channels found in all vertebrates that serve as a pathway for ATP release. In this article, we demonstrate that infection results in the opening of Panx1 channels in cardiac myocytes. We show that pharmacological blockade of Panx1 channels inhibits –induced [Ca] transients and invasion in cardiac myocytes. Our results indicate that opening of Panx1 channels are required for invasion in cardiac myocytes, and we propose that targeting Panx1 channel could provide new potential therapeutic approaches to treat Chagas disease.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.17-0293
2017-11-06
2017-11-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.17-0293
Loading
  • Published online : 06 Nov 2017
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error