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FN1Financial support: This work was funded by the International Centers for Excellence in Research program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, with travel support from the Public Health Agency of Canada.
FN2Authors' addresses: David Safronetz and L. Robbin Lindsay, National Microbiology Laboratory, Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Canada. E-mails: firstname.lastname@example.org and email@example.com. Nafomon Sogoba, Sory Ibrahim Diawara, Sidy Bane, Ousmane Maiga, Sekou F. Traore, and Seydou Doumbia, Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali, E-mails: firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, and email@example.com. Kyle Rosenke and Heinz Feldmann, Laboratory of Virology, National Institute of Allergy and Infectious Diseases, Hamilton, MT, E-mails: firstname.lastname@example.org and email@example.com. Matt Boisen and Luis M. Branco, Zalgen Labs LLC, Diagnostics, Germantown, MD, E-mails: firstname.lastname@example.org and email@example.com. Robert F. Garry, Medical Microbiology, Tulane University School of Medicine, New Orleans, LA, E-mail: firstname.lastname@example.org.
- The American Society of Tropical Medicine and Hygiene
- Source: The American Journal of Tropical Medicine and Hygiene, Volume 96, Issue 4, Apr 2017, p. 944 - 946
Annual Incidence of Lassa Virus Infection in Southern Mali
Previously, we reported a high seroprevalence rate of Lassa virus antibodies in inhabitants of three villages in southern Mali where infected rodents have been demonstrated. Herein, we report a 1-year follow-up study in which we were able to collect a second blood samples from 88.7% of participants of the same cohort. We identified 23 seroconversions for IgG antibodies reactive against Lassa virus, representing an incidence of 6.3% (95% confidence interval = 3.8–8.8%). Seroconversion was frequently seen in preteenage children (12/23, 51.7%) and two household/familial clusters were identified. These results confirm active transmission of Lassa virus is occurring in southern Mali and appropriate diagnostic testing should be established for this etiological agent of severe viral hemorrhagic fever.