1921
Volume 97, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract.

Intestinal infection caused by is a major contributor to diarrhea morbidity and mortality in young children around the world. Current treatments for children suffering from cryptosporidiosis are suboptimal. Lactoferrin is a glycoprotein found in breast milk. It has showed bacteriostatic and antimicrobial activity in the intestine. However, the effects of lactoferrin on the intestinal parasite have not been reported. In this study, we investigated the anticryptosporidial activity of human lactoferrin on different stages of . Physiologic concentrations of lactoferrin killed sporozoites, but had no significant effect on oocysts viability or parasite intracellular development. Since sporozoites are essential for the infection process, our data reinforce the importance of breastfeeding and point to the potential of lactoferrin as a novel therapeutic agent for cryptosporidiosis.

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/content/journals/10.4269/ajtmh.16-0804
2017-09-07
2017-09-20
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  • Received : 12 Oct 2016
  • Accepted : 07 May 2017

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