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FN1Authors' addresses: Ahmed Al Hammadi and Jennifer P. Wang, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, E-mails: email@example.com and firstname.lastname@example.org. Michael Mitchell, Department of Pathology, University of Massachusetts Medical School, Worcester, MA, E-mail: email@example.com. George M. Abraham, Saint Vincent Hospital, Worcester, MA, E-mail: firstname.lastname@example.org.
We present a case of a primigravid woman who presented with Plasmodium falciparum nearly 3 years after she last visited a malaria-endemic region. We review the literature to identify case reports of recrudescent P. falciparum malaria during pregnancy, including those with prolonged latency. Reports of recrudescence of P. falciparum during pregnancy are limited. Plasmodium falciparum infection can persist for years. Recrudescence can occur with waning of immunity following departure from endemic areas. Pregnancy, particularly the primigravid state, is a risk factor for severe infection.