1921
image of Antibody Responses to Plasmodium falciparum and Plasmodium vivax and Prospective Risk of Plasmodium spp. Infection Postpartum
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Postpartum women may have an altered susceptibility to and . The relationship between naturally acquired malarial immunity and susceptibility to malaria postpartum is yet to be determined. IgG levels were measured against and antigens from delivery in 201 postpartum and 201 nonpregnant controls over 12 weeks. Associations between time‐varying antibody levels and time to first microscopically confirmed species‐specific infection were determined by Cox regression. Associations between antibody levels and prospective risk of infection were similar in postpartum and control women. A 2‐fold increase in antibody levels was associated with increased prospective risk of infection (hazard ratio [HR] range = 1.37–1.94). Antibody levels against most antigens displayed no association with prospective risk of infection (HR range = 1.02–1.05) with the exception of MSP1 antibodies that were weakly associated with prospective risk of infection (HR = 1.14 (95% confidence interval = 1.02, 1.28) per 2‐fold increase in levels). Associations between antibody levels and prospective risk of infection attenuated when adjusted for documented retrospective exposure. Serology may be a useful tool to predict and monitor women at increased risk of infection postpartum, particularly in the absence of a detailed history of retrospective infections.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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/content/journals/10.4269/ajtmh.16-0690
2017-03-06
2017-03-26
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.16-0690
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  • Published online : 06 Mar 2017
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