1921
Volume 97, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract.

Tobacco use is a major risk factor for tuberculosis (TB). Secondhand smoke (SHS) is also a risk factor for TB and to a lesser extent, infection without disease. We investigated the added risk of infection due to SHS exposure in childhood contacts of TB cases in The Gambia. Participants were childhood household contacts aged ≤ 14 years of newly diagnosed pulmonary TB (PTB) cases. The intensity of exposure to the case was categorized according to whether contacts slept in the same room, same house, or a different house as the case. Contacts were tested with an enzyme-linked immunospot interferon gamma release assay. In multivariate regression models, infection was associated with increasing exposure to a case (odds ratios [OR]: 3.9, 95% confidence interval [CI]: 2.11–71.4, < 0.001]) and with male gender (OR: 1.5 [95% CI: 1.12–2.11], = 0.008). Tobacco use caused a 3-fold increase in the odds of infection in children who slept closest to a case who smoked within the same home compared with a nonsmoking case (OR: 8.0 [95% CI: 2.74–23.29] versus 2.4 [95% CI: 1.17–4.92], < 0.001). SHS exposure as an effect modifier appears to greatly increase the risk of infection in children exposed to PTB cases. Smoking cessation campaigns may be important for reducing transmission of to children within households.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.16-0611
2017-08-02
2017-12-13
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.16-0611
Loading
/content/journals/10.4269/ajtmh.16-0611
Loading

Data & Media loading...

Supplementary Data

Supplemental Table

  • Received : 27 Jul 2016
  • Accepted : 06 Apr 2017

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error