image of In Vitro Sensitivity of Cutaneous Leishmania Promastigote Isolates Circulating in French Guiana to a Set of Drugs
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Anti‐leishmaniasis drug resistance is a common problem worldwide. The aim of this study was to inventory the general in vitro level of sensitivity of isolates circulating in French Guiana and to highlight potential in vitro pentamidine‐resistant isolates. This sensitivity study was conducted on 36 patient‐promastigote isolates for seven drugs (amphotericin B, azithromycin, fluconazole, meglumine antimoniate, miltefosine, paromomycin, and pentamidine) using the Cell Counting Kit‐8 viability test. The IC values obtained were heterogeneous. One isolate exhibited high IC values for almost all drugs tested. Pentamidine, which is the first‐line treatment in French Guiana, showed efficacy at very low doses (mean of 0.0038 μg/mL). The concordance of the in vitro pentamidine results with the patients' clinical outcomes was 94% ( = 0.82).


Article metrics loading...

Loading full text...

Full text loading...

  • Published online : 06 Feb 2017
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error