1921
image of Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

is the causative agent of melioidosis, an emerging tropical disease of high mortality. Sub‐Saharan Africa represents potential melioidosis “hotspots”; however, to date, only a few cases have been reported. Herein, we compared the inflammatory patterns induced by a strain recently isolated from a fatal Gabonese case with the Thai reference strain ‐1026b and ‐E264. Ex vivo, no differences were observed in terms of cellular responsiveness between strains. However, when compared with the ‐1026b strain, the Gabonese isolate was significantly less virulent in terms of bacterial dissemination, inflammatory response, and organ damage in mice. Genomic comparison between strains showed differences in regions containing a fimbriae/adhesion virulence protein. In addition to a lack of microbiology facilities, differences in virulence of strains might contribute to the diverse global clinical occurrence of melioidosis.

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/content/journals/10.4269/ajtmh.16-0121
2017-03-13
2017-03-28
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.16-0121
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  • Published online : 13 Mar 2017
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