image of Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


is the causative agent of melioidosis, an emerging tropical disease of high mortality. Sub‐Saharan Africa represents potential melioidosis “hotspots”; however, to date, only a few cases have been reported. Herein, we compared the inflammatory patterns induced by a strain recently isolated from a fatal Gabonese case with the Thai reference strain ‐1026b and ‐E264. Ex vivo, no differences were observed in terms of cellular responsiveness between strains. However, when compared with the ‐1026b strain, the Gabonese isolate was significantly less virulent in terms of bacterial dissemination, inflammatory response, and organ damage in mice. Genomic comparison between strains showed differences in regions containing a fimbriae/adhesion virulence protein. In addition to a lack of microbiology facilities, differences in virulence of strains might contribute to the diverse global clinical occurrence of melioidosis.


Article metrics loading...

Loading full text...

Full text loading...

  • Published online : 13 Mar 2017
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error